Journal article
Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content
BMC Complementary and Alternative Medicine, Vol.12, 173
2012
Abstract
Background: The main aim of this study is to evaluate the antioxidant and anti-inflammatory properties of forty four traditional Chinese medicinal herbal extracts and to examine these activities in relation to their antioxidant content.Methods: The antioxidant activities were investigated using DPPH radical scavenging method and yeast model. The anti-inflammatory properties of the herbal extracts were evaluated by measuring their ability to inhibit the production of nitric oxide and TNF-ÃŽ± in RAW 264.7 macrophages activated by LPS and IFN- ÃŽÅ‚, respectively. The cytotoxic effects of the herbal extracts were determined by Alomar Blue assay by measuring cell viability. In order to understand the variation of antioxidant activities of herbal extracts with their antioxidant contents, the total phenolics, total flavonoids and trace metal (Mg, Mn, Cu, Zn, Se and Mo) quantities were estimated and a correlation analysis was carried out.Results: Results of this study show that significant levels of phenolics, flavonoids and trace metal contents were found in Ligustrum lucidum, Paeonia suffuticosa, Salvia miltiorrhiza, Sanguisorba officinalis, Spatholobus suberectus, Tussilago farfara and Uncaria rhyncophylla, which correlated well with their antioxidant and anti-inflammatory activities. Some of the plants displayed high antioxidant and anti-inflammatory activities but contained low levels of phenolics and flavonoids. Interestingly, these plants contained significant levels of trace metals (such as Zn, Mg and Se) which are likely to be responsible for their activities.Conclusions: The results indicate that the phenolics, flavonoids and trace metals play an important role in the antioxidant activities of medicinal plants. Many of the plants studied here have been identified as potential sources of new antioxidant compounds.
Details
- Title
- Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content
- Authors
- A S Ravipati (Author) - University of Western SydneyL Zhang (Author) - University of Western SydneyS R Koyyalamudi (Author) - University of Western SydneyS C Jeong (Author) - University of Western SydneyN Reddy (Author) - University of Western SydneyJohn R Bartlett (Author) - University of Western SydneyP T Smith (Author) - University of Western SydneyK Shanmugam (Author) - University of Western SydneyG MÄ‚Å’nch (Author) - University of Western SydneyM J Wu (Author) - University of Western SydneyM Satyanarayanan (Author) - CSIR-National Geophysical Research Institute, IndiaB Vysetti (Author) - CSIR-National Geophysical Research Institute, India
- Publication details
- BMC Complementary and Alternative Medicine, Vol.12, 173; 14
- Publisher
- BioMed Central Ltd.
- Date published
- 2012
- DOI
- 10.1186/1472-6882-12-173
- ISSN
- 1472-6882
- Copyright note
- Copyright © 2012 Ravipati et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99448851502621
- Output Type
- Journal article
Metrics
41 File views/ downloads
982 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Integrative & Complementary Medicine
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites