Journal article
Antidepressant Use Among People Prescribed Opioids for Chronic Noncancer Pain
Pain Medicine, Vol.20(12), pp.2450-2458
2019
PMID: 30861530
Abstract
Abstract Objective Although depression and chronic pain often coexist, few studies have examined antidepressant use among people with pain. This study examines the prevalence and characteristics associated with antidepressant use among people prescribed opioids for chronic noncancer pain (CNCP). Design Baseline data from a prospective cohort study. Setting Australian community. Subjects A total of 1166 people prescribed opioids for CNCP. Methods Baseline data collection consisted of a self-completed seven-day medication diary and telephone interview to collect information on sociodemographic characteristics and mental/physical health using validated questionnaires. Logistic regression was used to examine characteristics associated with antidepressant use, reporting adjusted odds ratios (AORs) and 95% confidence intervals (CIs). Results Of the 1166 participants, 668 (57.3%) were female, and the median (interquartile range) age was 59 (49–68) years. About half the cohort (N = 637, 54.6%) used antidepressants. Of these, 329 (51.7%) reported moderate to severe depression. Amitriptyline was the most commonly used antidepressant (17.3%). Factors independently associated with antidepressant use were being female (AOR = 1.47, 95% CI = 1.13–1.92), more years lived in pain (AOR = 1.01, 95% CI = 1.00–1.02), and use of nonopioid analgesics (AOR = 1.34, 95% CI = 1.01–1.78), benzodiazepines and related drugs (AOR = 1.84, 95% CI = 1.36–2.49), antiepileptics (AOR = 1.86, 95% CI = 1.38–2.51), and antipsychotics (AOR = 2.15, 95% CI = 1.22–3.77). Conclusions Antidepressant use is common among people with CNCP prescribed opioids. Those using antidepressants were more likely to use other psychotropic medicines concurrently, highlighting that they are a high-risk population requiring comprehensive assessment to optimize outcomes and reduce potential harms from polypharmacy.
Details
- Title
- Antidepressant Use Among People Prescribed Opioids for Chronic Noncancer Pain
- Authors
- Natasa Gisev (Corresponding Author) - UNSW AustraliaSuzanne Nielsen (Author) - UNSW AustraliaGabrielle Campbell (Author) - UNSW AustraliaThomas Santo (Author) - UNSW AustraliaAndrea Mant (Author) - UNSW AustraliaRaimondo Bruno (Author) - University of TasmaniaMilton Cohen (Author) - UNSW AustraliaWayne D Hall (Author) - University of QueenslandBriony Larance (Author) - UNSW AustraliaNicholas Lintzeris (Author) - University of SydneyMichael Farrell (Author) - UNSW AustraliaLouisa Degenhardt (Author) - UNSW Australia
- Publication details
- Pain Medicine, Vol.20(12), pp.2450-2458
- Publisher
- Oxford University Press
- DOI
- 10.1093/pm/pnz009
- ISSN
- 1526-4637
- PMID
- 30861530
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99472500102621
- Output Type
- Journal article
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