Journal article
Antibody levels to the class I and II epitopes of the M protein and myosin are related to group A streptococcal exposure in endemic populations
International Immunology, Vol.13(10), pp.1335-1343
2001
Abstract
Rheumatic fever (RF)/rheumatic heart disease (RHD) and post-streptococcal glomerulonephritis are thought to be autoimmune diseases, and follow group A streptococcal (GAS) infection. Different GAS M types have been associated with rheumatogenicity or nephritogenicity and categorized into either of two distinct classes (I or II) based on amino acid sequences present within the repeat region (`C' repeats) of the M protein. Sera from ARF patients have previously been shown to contain elevated levels of antibodies to the class I-specific epitope and myosin with the class I-specific antibodies also being cross-reactive to myosin, suggesting a disease association. This study shows that immunoreactivity of the class I-specific peptide and myosin does not differ between controls and acute RF (ARF)/RHD in populations that are highly endemic for GAS, raising the possibility that the association is related to GAS exposure, not the presence of ARF/RHD. Peptide inhibition studies suggest that the class I epitope may be conformational and residue 10 of the peptide is critical for antibody binding. We demonstrate that correlation of antibody levels between the class I and II epitope is due to class II-specific antibodies recognizing a common epitope with class I which is contained within the sequence RDL-ASRE. Our results suggest that antibody prevalence to class I and II epitopes and myosin is associated with GAS exposure, and that antibodies to these epitopes are not an indicator of disease nor a pathogenic factor in endemic populations.
Details
- Title
- Antibody levels to the class I and II epitopes of the M protein and myosin are related to group A streptococcal exposure in endemic populations
- Authors
- E R Brandt (Author) - Queensland Institute of Medical ResearchP J Yarwood (Author) - Queensland Institute of Medical ResearchDavid J McMillan (Author) - Queensland Institute of Medical ResearchH Vohra (Author) - Post-graduate Institute of Medical Education and Research, IndiaB Currie (Author) - Menzies School of Health Research, AustraliaK Mammo (Author) - King Faisal Specialist Hospital and Research Centre, Saudi ArabiaS Pruksakorn (Author) - Chaing Mai University, ThailandJ Saour (Author) - King Faisal Specialist Hospital and Research Centre, Saudi ArabiaM F Good (Author) - Queensland Institute of Medical Research
- Publication details
- International Immunology, Vol.13(10), pp.1335-1343
- Publisher
- Oxford University Press
- Date published
- 2001
- DOI
- 10.1093/intimm/13.10.1335
- ISSN
- 0953-8178
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450386002621
- Output Type
- Journal article
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