Antibacterial 5α-Spirostane Saponins from the Fruit of Cordyline manners-suttoniae

Trong D Tran; Malin A Olsson; Md Abu Choudhury; David J McMillan; J K Cullen; P G Parsons; P V Bernhardt; P W Reddell; Steven Ogbourne

doi:10.1021/acs.jnatprod.9b00502

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Antibacterial 5α-Spirostane Saponins from the Fruit of Cordyline manners-suttoniae

Journal article

Peer reviewed

Antibacterial 5α-Spirostane Saponins from the Fruit of Cordyline manners-suttoniae

Trong D Tran, Malin A Olsson, Md Abu Choudhury, David J McMillan, J K Cullen, P G Parsons, P V Bernhardt, P W Reddell and Steven Ogbourne

Journal of Natural Products, Vol.82(10), pp.2809-2817

2019

DOI: https://doi.org/10.1021/acs.jnatprod.9b00502

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Abstract

Antibacterial-activity-guided fractionation of a dichloromethane extract from the fruit of Cordyline manners-suttoniae and subsequent structure-activity investigations resulted in the identification of 10 new (1-10) and one known (11) 5α-spirostane saponin. The structures of the new compounds were established by 1D and 2D NMR analyses. The absolute configurations of the isolated compounds were determined by X-ray diffraction analysis or chemical derivatizations. The most active compound, suttonigenin F (6), inhibited the Gram-positive bacteria Staphylococcus aureus with MIC75 values that were comparable to those of the antibiotic chloramphenicol. Structure-activity relationships were also obtained from the assessment of antibacterial and cytotoxic activities of the isolated saponins.

Details

Title: Antibacterial 5α-Spirostane Saponins from the Fruit of Cordyline manners-suttoniae
Authors: Trong D Tran (Author) - University of the Sunshine Coast
Malin A Olsson (Author) - University of the Sunshine Coast - School of Health & Sports Sciences
Md Abu Choudhury (Author) - University of the Sunshine Coast - School of Health & Sports Sciences
David J McMillan (Author) - University of the Sunshine Coast - School of Health & Sports Sciences
J K Cullen (Author)
P G Parsons (Author)
P V Bernhardt (Author)
P W Reddell (Author)
Steven Ogbourne (Author) - University of the Sunshine Coast
Publication details: Journal of Natural Products, Vol.82(10), pp.2809-2817
Publisher: American Chemical Society
Date published: 2019
DOI: 10.1021/acs.jnatprod.9b00502
ISSN: 0163-3864
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450762402621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Chemistry, Medicinal; Pharmacology & Pharmacy; Plant Sciences

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