Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

Weile Ye; Jiaojiao Wang; Peter J Little; Jiami Zou; Zhihua Zheng; Jing Lu; Yanjun Yin; Hao Liu; Dongmei Zhang; Peiqing Liu; Suowen Xu; Wencai Ye; Zhiping Liu

doi:10.1016/j.apsb.2023.09.014

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Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

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Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

Weile Ye, Jiaojiao Wang, Peter J Little, Jiami Zou, Zhihua Zheng, Jing Lu, Yanjun Yin, Hao Liu, Dongmei Zhang, Peiqing Liu, …

Acta Pharmaceutica Sinica B, Vol.14(1), pp.1-19

2024

DOI: https://doi.org/10.1016/j.apsb.2023.09.014

PMCID: PMC10792990

PMID: 38239238

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Abstract

Cardiovascular disease

Atherosclerosis

Ginkgo biloba

Ginkgolide B

Endothelial dysfunction

LOX-1

PCSK9

PAF-R antagonist

Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases (CVDs), the world’s primary cause of death. Ginkgo biloba, a well-known traditional Chinese medicine with notable cardiovascular actions, has been used as a cardio- and cerebrovascular therapeutic drug and nutraceutical in Asian countries for centuries. Preclinical studies have shown that ginkgolide B, a bioactive component in Ginkgo biloba, can ameliorate atherosclerosis in cultured vascular cells and disease models. Of clinical relevance, several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases, such as ischemia stroke. Here, we present a comprehensive review of the pharmacological activities, pharmacokinetic characteristics, and mechanisms of action of ginkgolide B in atherosclerosis prevention and therapy. We highlight new molecular targets of ginkgolide B, including nicotinamide adenine dinucleotide phosphate oxidases (NADPH oxidase), lectin-like oxidized LDL receptor-1 (LOX-1), sirtuin 1 (SIRT1), platelet-activating factor (PAF), proprotein convertase subtilisin/kexin type 9 (PCSK9) and others. Finally, we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis.

Details

Title: Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba
Authors: Weile Ye (Author) - Jinan University
Jiaojiao Wang (Author) - Jinan University
Peter J Little (Author) - University of the Sunshine Coast, Queensland, School of Health
Jiami Zou (Author) - Jinan University
Zhihua Zheng (Author) - Jinan University
Jing Lu (Author) - Sun Yat-sen University
Yanjun Yin (Author) - Bengbu Medical College
Hao Liu (Author) - Bengbu Medical College
Dongmei Zhang (Author) - Jinan University
Peiqing Liu (Author) - Sun Yat-sen University
Suowen Xu (Author) - Bengbu Medical College
Wencai Ye (Author) - Jinan University
Zhiping Liu (Corresponding Author) - Jinan University
Publication details: Acta Pharmaceutica Sinica B, Vol.14(1), pp.1-19
Publisher: Elsevier BV
Date published: 2024
DOI: 10.1016/j.apsb.2023.09.014
ISSN: 2211-3843
PMID: 38239238; PMC10792990
Copyright note: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
Grant note: 82270500, 81870324, 82203304, 82070464, U1401225, U21A20419 / National Natural Science Foundation of China 2019ZX09735002 / National Mega-Project for Innovative Drugs 2017BT01Y036, 2017BT01Y093 / Guangdong Pearl River Talents Program, China 2017B090903004 / National Engineering and Technology Research Center, China
Organisation Unit: School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99971198302621
Output Type: Journal article

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