Anti-P. gingivalis response correlates with atherosclerosis

P J Ford; E Gemmell; Peter Timms; A Chan; F M Preston; G J Seymour

doi:10.1177/154405910708600105

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Anti-P. gingivalis response correlates with atherosclerosis

Journal article

Peer reviewed

Anti-P. gingivalis response correlates with atherosclerosis

P J Ford, E Gemmell, Peter Timms, A Chan, F M Preston and G J Seymour

Journal of Dental Research, Vol.86(1), pp.35-40

2007

DOI: https://doi.org/10.1177/154405910708600105

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Abstract

porphyromonas gingivalis

periodontal disease

antibody response

atherosclerosis

mouse model

Significant associations between atherosclerosis and both Porphyromonas gingivalis, a major periodontopathogen, and the respiratory pathogen, Chlamydia pneumoniae, have been shown. Many individuals with evidence of atherosclerosis demonstrate seropositivity to these pathogens. The aim of the present study was to examine the atherogenic effect of repeated immunizations with either or both of these agents, and to determine if molecular mimicry of bacterial heat-shock protein (HSP), termed GroEL, and host (h) HSP60 was involved. Atherogenesis was examined in apolipoprotein-E-deficient (-/-) mice following intraperitoneal immunizations with P. gingivalis, C. pneumoniae, P. gingivalis, and C. pneumoniae or vehicle. Lesion area in the proximal aorta and levels of serum antibodies to P. gingivalis, C. pneumoniae, and GroEL were measured. The increased pathogen burden of P. gingivalis, but not of C. pneumoniae, enhanced atherosclerosis. hHSP60 was detected in lesions, and in P. gingivalis-immunized mice, lesion development was correlated with anti-GroEL antibody levels, supporting the involvement of molecular mimicry between GroEL and hHSP60.

Details

Title: Anti-P. gingivalis response correlates with atherosclerosis
Authors: P J Ford (Author) - University of Queensland
E Gemmell (Author) - University of Queensland
Peter Timms (Author) - Queensland University of Technology
A Chan (Author) - University of Queensland
F M Preston (Author) - University of Queensland
G J Seymour (Author) - University of Queensland
Publication details: Journal of Dental Research, Vol.86(1), pp.35-40
Publisher: Sage Publications Inc.
Date published: 2007
DOI: 10.1177/154405910708600105
ISSN: 0022-0345
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449899602621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Dentistry, Oral Surgery & Medicine

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