Journal article
Anti-P. gingivalis response correlates with atherosclerosis
Journal of Dental Research, Vol.86(1), pp.35-40
2007
Abstract
Significant associations between atherosclerosis and both Porphyromonas gingivalis, a major periodontopathogen, and the respiratory pathogen, Chlamydia pneumoniae, have been shown. Many individuals with evidence of atherosclerosis demonstrate seropositivity to these pathogens. The aim of the present study was to examine the atherogenic effect of repeated immunizations with either or both of these agents, and to determine if molecular mimicry of bacterial heat-shock protein (HSP), termed GroEL, and host (h) HSP60 was involved. Atherogenesis was examined in apolipoprotein-E-deficient (-/-) mice following intraperitoneal immunizations with P. gingivalis, C. pneumoniae, P. gingivalis, and C. pneumoniae or vehicle. Lesion area in the proximal aorta and levels of serum antibodies to P. gingivalis, C. pneumoniae, and GroEL were measured. The increased pathogen burden of P. gingivalis, but not of C. pneumoniae, enhanced atherosclerosis. hHSP60 was detected in lesions, and in P. gingivalis-immunized mice, lesion development was correlated with anti-GroEL antibody levels, supporting the involvement of molecular mimicry between GroEL and hHSP60.
Details
- Title
- Anti-P. gingivalis response correlates with atherosclerosis
- Authors
- P J Ford (Author) - University of QueenslandE Gemmell (Author) - University of QueenslandPeter Timms (Author) - Queensland University of TechnologyA Chan (Author) - University of QueenslandF M Preston (Author) - University of QueenslandG J Seymour (Author) - University of Queensland
- Publication details
- Journal of Dental Research, Vol.86(1), pp.35-40
- Publisher
- Sage Publications Inc.
- DOI
- 10.1177/154405910708600105
- ISSN
- 0022-0345
- Organisation Unit
- University of the Sunshine Coast, Queensland; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99449899602621
- Output Type
- Journal article