Anti-Inflammatory Diets in Fertility: An Evidence Review

Simon   Alesi; Anthony Villani; Evangeline Mantzioris; Wubet Worku Takele; Stephanie Cowan; Lisa Moran; Aya Mousa

doi:10.3390/nu14193914

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Anti-Inflammatory Diets in Fertility: An Evidence Review

Journal article

Open access

Peer reviewed

Anti-Inflammatory Diets in Fertility: An Evidence Review

Simon Alesi, Anthony Villani, Evangeline Mantzioris, Wubet Worku Takele, Stephanie Cowan, Lisa Moran and Aya Mousa

Nutrients, Vol.14(9), pp.1-21

2022

DOI: https://doi.org/10.3390/nu14193914

PMCID: PMC9570802

PMID: 36235567

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Abstract

anti-inflammatory diet

fertility

infertility

preconception

nutrition

supplementation

lifestyle

proinflammatory

Review

Mediterranean diet

reproductive health and diseases

Infertility is a global health concern affecting 48 million couples and 186 million individuals worldwide. Infertility creates a significant economic and social burden for couples who wish to conceive and has been associated with suboptimal lifestyle factors, including poor diet and physical inactivity. Modifying preconception nutrition to better adhere with Food-Based Dietary Guidelines (FBDGs) is a non-invasive and potentially effective means for improving fertility outcomes. While several dietary patterns have been associated with fertility outcomes, the mechanistic links between diet and infertility remain unclear. A key mechanism outlined in the literature relates to the adverse effects of inflammation on fertility, potentially contributing to irregular menstrual cyclicity, implantation failure, and other negative reproductive sequelae. Therefore, dietary interventions which act to reduce inflammation may improve fertility outcomes. This review consistently shows that adherence to anti-inflammatory diets such as the Mediterranean diet (specifically, increased intake of monounsaturated and n-3 polyunsaturated fatty acids, flavonoids, and reduced intake of red and processed meat) improves fertility, assisted reproductive technology (ART) success, and sperm quality in men. Therefore, integration of anti-inflammatory dietary patterns as low-risk adjunctive fertility treatments may improve fertility partially or fully and reduce the need for prolonged or intensive pharmacological or surgical interventions.

Details

Title: Anti-Inflammatory Diets in Fertility: An Evidence Review
Authors: Simon Alesi (Author) - Monash University
Anthony Villani (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Evangeline Mantzioris (Author) - University of South Australia
Wubet Worku Takele (Author) - Monash University
Stephanie Cowan (Author) - Monash University
Lisa Moran (Author) - Monash University
Aya Mousa (Corresponding Author) - Monash University
Publication details: Nutrients, Vol.14(9), pp.1-21
Publisher: MDPI AG
Date published: 2022
DOI: 10.3390/nu14193914
ISSN: 2072-6643
PMID: 36235567; PMC9570802
Copyright note: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health - Nutrition & Dietetics; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99678897802621
Output Type: Journal article

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Web Of Science research areas: Nutrition & Dietetics

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