Anti-Correlated Myelin-Sensitive MRI Levels in Humans Consistent with a Subcortical to Sensorimotor Regulatory Process—Multi-Cohort Multi-Modal Evidence

Leighton Barnden; Benjamin Crouch; Richard Kwiatek; Zack Shan; Kiran Thapaliya; Donald Staines; Sandeep Bhuta; Peter Del Fante; Richard Burnet

doi:10.3390/brainsci12121693

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Anti-Correlated Myelin-Sensitive MRI Levels in Humans Consistent with a Subcortical to Sensorimotor Regulatory Process—Multi-Cohort Multi-Modal Evidence

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Anti-Correlated Myelin-Sensitive MRI Levels in Humans Consistent with a Subcortical to Sensorimotor Regulatory Process—Multi-Cohort Multi-Modal Evidence

Leighton Barnden, Benjamin Crouch, Richard Kwiatek, Zack Shan, Kiran Thapaliya, Donald Staines, Sandeep Bhuta, Peter Del Fante and Richard Burnet

Brain Sciences, Vol.12(12), pp.1-14

2022

DOI: https://doi.org/10.3390/brainsci12121693

PMID: 36552153

Appears in Thompson Institute Research Collection

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Abstract

amygdala

hippocampus

human

hypothalamus

interneurons

myelin

regulation

reticular activation system

sensorimotor

subcortical

Other Collaborations

Thompson Institute Special Collection

Differential axonal myelination synchronises signalling over different axon lengths. The consequences of myelination processes described at the cellular level for the regulation of myelination at the macroscopic level are unknown. We analysed multiple cohorts of myelin-sensitive brain MRI. Our aim was to (i) confirm a previous report of anti-correlation between myelination in subcortical and sensorimotor areas in healthy subjects, (ii) and thereby test our hypothesis for a regulatory interaction between them. We analysed nine image-sets across three different human cohorts using six MRI modalities. Each image-set contained healthy controls (HC) and ME/CFS subjects. Subcortical and Sensorimotor regions of interest (ROI) were optimised for the detection of anti-correlations and the same ROIs were used to test the HC in all image-sets. For each cohort, median MRI values were computed in both regions for each subject and their correlation across the cohort was computed. We confirmed negative correlations in healthy controls between subcortical and sensorimotor regions in six image-sets: three T1wSE (p = 5 × 10−8, 5 × 10−7, 0.002), T2wSE (p =2 × 10−6), MTC (p = 0.01), and WM volume (p = 0.02). T1/T2 was the exception with a positive correlation (p = 0.01). This myelin regulation study is novel in several aspects: human subjects, cross-sectional design, ROI optimization, spin-echo MRI and reproducible across multiple independent image-sets. In multiple independent image-sets we confirmed an anti-correlation between subcortical and sensorimotor myelination which supports a previously unreported regulatory interaction. The subcortical region contained the brain’s primary regulatory nuclei. We suggest a mechanism has evolved whereby relatively low subcortical myelination in an individual is compensated by upregulated sensorimotor myelination to maintain adequate sensorimotor performance.

Details

Title: Anti-Correlated Myelin-Sensitive MRI Levels in Humans Consistent with a Subcortical to Sensorimotor Regulatory Process—Multi-Cohort Multi-Modal Evidence
Authors: Leighton Barnden (Corresponding Author) - Griffith University
Benjamin Crouch (Author) - Royal Adelaide Hospital
Richard Kwiatek (Author) - Lyell McEwin Hospital
Zack Shan (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Kiran Thapaliya (Author) - Griffith University
Donald Staines (Author) - Griffith University
Sandeep Bhuta (Author) - Gold Coast Hospital
Peter Del Fante (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Richard Burnet (Author) - Royal Adelaide Hospital
Publication details: Brain Sciences, Vol.12(12), pp.1-14
Publisher: MDPI AG
Date published: 2022
DOI: 10.3390/brainsci12121693
ISSN: 2076-3425
PMID: 36552153
Copyright note: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Grant note: Alison Hunter Memorial Foundation Judith Jane Mason Foundation Stafford Fox Medical Research Foundation Queen Elizabeth Hospital Nuclear Medicine Fund John T Reid Charitable Trusts
Organisation Unit: Thompson Institute
Language: English
Record Identifier: 99695749502621
Output Type: Journal article

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