Anterior‐posterior electrophysiological activity characterizes Parkinsonian visual misperceptions

Alana J. Muller; James M Shine; Camarin E. Rolle; Kate M Chitty; Julie M Hall; Glenda M. Halliday; Daniel Hermens; Simon J G Lewis; Claire O’Callaghan

doi:10.1111/ncn3.12508

Back

Anterior‐posterior electrophysiological activity characterizes Parkinsonian visual misperceptions

Journal article

Peer reviewed

Anterior‐posterior electrophysiological activity characterizes Parkinsonian visual misperceptions

Alana J. Muller, James M Shine, Camarin E. Rolle, Kate M Chitty, Julie M Hall, Glenda M. Halliday, Daniel Hermens, Simon J G Lewis and Claire O’Callaghan

Neurology and Clinical Neuroscience, Vol.9(4), pp.312-318

2021

DOI: https://doi.org/10.1111/ncn3.12508

Files and links (2)

url

https://doi.org/10.1111/ncn3.12508View

Published Version

url

https://onlinelibrary.wiley.com/doi/full/10.1111/ncn3.12508View

Webpage

Abstract

Neurosciences

Expanding knowledge in the health sciences

EEG

electrophysiology

hallucinations

misperceptions

Parkinson's disease

Other Collaborations

Thompson Institute Special Collection

Background: The neural mechanism underlying visual hallucinations (VH) in Parkinson's disease (PD) relates to impaired network-level communication; however, the timing of this effect is poorly understood. Aim: To elucidate the temporal evolution of EEG signals during misperceptions in PD patients. Methods: Twenty-seven patients with PD performed a validated behavioral task (the bistable percept paradigm, BPP) capable of eliciting visual misperceptions while being monitored using scalp electroencephalography (EEG). Using a data-driven clustering analysis, EEG electrodes behaving similarly over time were clustered together. Misperceptions on the BPP were then related to the clustered time-series EEG patterns. Results: Patients with PD demonstrated distinctly different EEG signals during misperceptions, highlighted by early frontal and late posterior activity. Additionally, different aspects of the electrophysiological response during misperceptions were correlated with hallucination severity. Conclusions: Our results provide evidence that VH in PD may be related to early activity in frontal regions followed by activity within posterior regions of the cortex. These results support specific predictions of hypothetical models that emphasize an imbalance in top-down vs bottom-up processing during misperceptions and advance our understanding of the pathophysiology of VH in PD.

Details

Title: Anterior‐posterior electrophysiological activity characterizes Parkinsonian visual misperceptions
Authors: Alana J. Muller (Author) - University of Sydney
James M Shine (Corresponding Author) - University of Sydney
Camarin E. Rolle (Author) - Stanford University
Kate M Chitty (Author) - University of Sydney
Julie M Hall (Author) - University of Sydney
Glenda M. Halliday (Author) - University of Sydney
Daniel Hermens (Author) - University of Sydney
Simon J G Lewis (Author) - University of Sydney
Claire O’Callaghan (Author) - University of Sydney
Publication details: Neurology and Clinical Neuroscience, Vol.9(4), pp.312-318
Publisher: John Wiley & Sons (Asia) Pte. Ltd.
DOI: 10.1111/ncn3.12508
ISSN: 2049-4173
Organisation Unit: Thompson Institute; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99644179202621
Output Type: Journal article

Metrics

11 Record Views

2 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites