Anterior segment applications of optical coherence elastography in ophthalmic and vision science: a systematic review of intrinsic measurement techniques and clinical relevance

Zachery Quince; Nicola Westerman; David Alonso-Caneiro; Scott A Read; Michael Collins

doi:10.1088/2516-1091/add4d9

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Anterior segment applications of optical coherence elastography in ophthalmic and vision science: a systematic review of intrinsic measurement techniques and clinical relevance

Journal article

Open access

Peer reviewed

Anterior segment applications of optical coherence elastography in ophthalmic and vision science: a systematic review of intrinsic measurement techniques and clinical relevance

Zachery Quince, Nicola Westerman, David Alonso-Caneiro, Scott A Read and Michael Collins

Progress in Biomedical Engineering (Bristol), Vol.7(3), pp.1-19

2025

DOI: https://doi.org/10.1088/2516-1091/add4d9

PMID: 40328290

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Abstract

clinical translation

biomechanics

Optical coherence elastography

ocular disease management

tissue characterisation

Optical Coherence Elastography (OCE) is a non-invasive imaging technique that measures the biomechanical properties of materials and tissues. This systematic review focuses on the applications of OCE in the anterior segment of the eye, including the cornea, iris, and crystalline lens, and its clinical relevance in diagnosing and managing ocular diseases. A systematic literature review was conducted using the PRISMA framework to identify studies published between 2014 and 2024. The review included studies that reported intrinsic biomechanical properties of anterior segment tissues measured using OCE. Databases searched included Scopus, Pub Med, and IEEE Xplore. Twenty-five studies met the inclusion criteria. The review found that OCE has been used to measure intrinsic biomechanical parameters such as Young's modulus and shear modulus in ocular tissues. OCE has been utilised to assess corneal stiffness in keratoconus, lens elasticity in presbyopia and cataract formation, and iris biomechanical changes under different lighting conditions. The studies demonstrated that OCE could detect subtle biomechanical changes associated with ocular diseases and measure treatment efficacy, such as collagen crosslinking for keratoconus management. The findings highlight the potential of OCE to enhance clinical diagnostics and patient care by providing detailed insights into the biomechanical properties of ocular tissues. However, variability in measurement techniques, the complexity of the method and reliance on animal models limit the current clinical translation of OCE. Standardised measurement protocols and further development and in vivo validation are needed to overcome these barriers. OCE shows promise as a valuable non-invasive tool for high-resolution assessments of tissue biomechanics, which can subsequently support the diagnosis and management of ocular diseases. Future research should focus on standardising OCE methods and integrating them into clinical practice to fully realise their potential in improving patient outcomes.

Details

Title: Anterior segment applications of optical coherence elastography in ophthalmic and vision science: a systematic review of intrinsic measurement techniques and clinical relevance
Authors: Zachery Quince (Corresponding Author) - Queensland University of Technology
Nicola Westerman - University of Southern Queensland
David Alonso-Caneiro - University of the Sunshine Coast, Queensland, School of Science, Technology and Engineering
Scott A Read - Queensland University of Technology
Michael Collins - Queensland University of Technology
Publication details: Progress in Biomedical Engineering (Bristol), Vol.7(3), pp.1-19
Publisher: Institute of Physics Publishing Ltd.
Date published: 2025
DOI: 10.1088/2516-1091/add4d9
ISSN: 2516-1091
PMID: 40328290
Copyright note: (c) 2025 The Author(s). Published by IOP Publishing Ltd. Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Data Availability: All data that support the findings of this study are included within the article (and any supplementary information files).
Grant note: This work was funded by the University of Southern Queensland through a Research Collaboration Grant with Queensland University of Technology.
Organisation Unit: School of Science, Technology and Engineering
Language: English
Record Identifier: 991129999102621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Engineering, Biomedical

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