Angiotensin receptors as sensitive marker of acute bronchiole injury post lung transplantation

Maria Nataatmadja; Margaret Passmore; Fraser D Russell; Sulistiana Prabowo; Amanda Corley; John F Fraser

doi:10.1007/s00408-014-9588-3

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Angiotensin receptors as sensitive marker of acute bronchiole injury post lung transplantation

Journal article

Peer reviewed

Angiotensin receptors as sensitive marker of acute bronchiole injury post lung transplantation

Maria Nataatmadja, Margaret Passmore, Fraser D Russell, Sulistiana Prabowo, Amanda Corley and John F Fraser

Lung: an international journal on lungs, airways and breathing, Vol.192(4), pp.563-569

2014

DOI: https://doi.org/10.1007/s00408-014-9588-3

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Abstract

lung transplant

brochiole injury

angiotensin receptor

matric metalloproteinases

Background: Although lung transplantation is the only means of survival for patients with end-stage pulmonary disease, outcomes from this intervention are inferior to other solid organ transplants. The reason for the poor outcomes may be linked to an early reaction, such as primary graft dysfunction, and associated with marked inflammatory response, bronchiole injury, and later fibrotic responses. Mediators regulating these effects include angiotensin II and matrix metalloproteinases (MMPs). Methods: We investigated changes to these mediators over the course of cardiopulmonary bypass (CPB) and up to 72 h after lung transplantation, using immunohistochemistry, Western blot, and ELISA techniques. Results: We found 4- and 16-fold increases in plasma angiotensin II and MMP-9, respectively, from pre-CPB to post-CPB. MMP-9 levels remained elevated 1 h after transplantation. MMP-2 levels were elevated 6-24 h after lung transplantation. Type 2 angiotensin II receptor (ATR2) expression was 3.5-fold higher in bronchoalveolar cells 1-6 h after transplantation than in controls. Conclusions: The study suggests that the combination of cardiopulmonary bypass and lung transplantation is associated with early changes in the angiotensin II receptor system and in MMPs, and that altered expression of these mediators may be a useful marker to examine pathological changes that occur in lungs during transplant surgery.

Details

Title: Angiotensin receptors as sensitive marker of acute bronchiole injury post lung transplantation
Authors: Maria Nataatmadja (Author) - University of Queensland
Margaret Passmore (Author) - University of Queensland
Fraser D Russell (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Sulistiana Prabowo (Author) - Hang Tuah University, Indonesia
Amanda Corley (Author) - University of Queensland
John F Fraser (Author) - University of Queensland
Publication details: Lung: an international journal on lungs, airways and breathing, Vol.192(4), pp.563-569
Publisher: Springer New York LLC
Date published: 2014
DOI: 10.1007/s00408-014-9588-3
ISSN: 0341-2040
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99448987002621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Respiratory System

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