Journal article
Angiogenic response to passive movement and active exercise in individuals with peripheral arterial disease
Journal of Applied Physiology, Vol.115(12), pp.1777-1787
2013
Abstract
Peripheral arterial disease (PAD) is caused by atherosclerosis and is associated with microcirculatory impairments in skeletal muscle. The present study evaluated the angiogenic response to exercise and passive movement in skeletal muscle of PAD patients compared with healthy control subjects. Twenty-one PAD patients and 17 aged control subjects were randomly assigned to either a passive movement or an active exercise study. Interstitial fluid microdialysate and tissue samples were obtained from the thigh skeletal muscle. Muscle dialysate vascular endothelial growth factor (VEGF) levels were modestly increased in response to either passive movement or active exercise in both subject groups. The basal muscle dialysate level of the angiostatic factor thrombospondin-1 protein was markedly higher (P less than 0.05) in PAD patients compared with the control subjects, whereas soluble VEGF receptor-1 dialysate levels were similar in the two groups. The basal VEGF protein content in the muscle tissue samples was approximately 27% lower (P less than 0.05) in the PAD patients compared with the control subjects. Analysis of mRNA expression for a range of angiogenic and angiostatic factors revealed a modest change with active exercise and passive movement in both groups, except for an increase (P less than 0.05) in the ratio of angiopoietin-2 to angiopoietin-1 mRNA in the PAD group with both interventions. PAD patients and aged individuals showed a similar limited angiogenic response to active exercise and passive movement. The limited increase in muscle extracellular VEGF combined with an elevated basal level of thrombospondin-1 in muscle extracellular fluid of PAD patients may restrict capillary growth in these patients.
Details
- Title
- Angiogenic response to passive movement and active exercise in individuals with peripheral arterial disease
- Authors
- Birgitte Hoier (Author) - University of Copenhagen, DenmarkMeegan A Walker (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringMadla Passos (Author) - University of Copenhagen, DenmarkPhilip Walker (Author) - University of QueenslandAnita Green (Author) - University of QueenslandJens Bangsbo (Author) - University of Copenhagen, DenmarkChristopher D Askew (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringYlva Hellsten (Author) - University of Copenhagen, Denmark
- Publication details
- Journal of Applied Physiology, Vol.115(12), pp.1777-1787
- Publisher
- American Physiological Society
- Date published
- 2013
- DOI
- 10.1152/japplphysiol.00979.2013
- ISSN
- 8750-7587
- Copyright note
- Copyright © 2013 American Physiological Society. The author's accepted version is reproduced here in accordance with the publisher's copyright policy. The final definitive version is available at: http://dx.doi.org/10.1152/japplphysiol.00979.2013
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99449063802621
- Output Type
- Journal article
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