Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorder

A Fornito; G S Malhi; Jim Lagopoulos; B Ivanovski; S J Wood; M M Saling; C Pantelis; M Yücel

doi:10.1016/j.pscychresns.2007.06.004

Back

Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorder

Journal article

Peer reviewed

Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorder

A Fornito, G S Malhi, Jim Lagopoulos, B Ivanovski, S J Wood, M M Saling, C Pantelis and M Yücel

Psychiatry Research: Neuroimaging, Vol.162(2), pp.123-132

2008

DOI: https://doi.org/10.1016/j.pscychresns.2007.06.004

Files and links (1)

url

https://doi.org/10.1016/j.pscychresns.2007.06.004View

Published Version

Abstract

prefrontal

depression

mood

voxel

gyrification

psychosis

Abnormalities of the anterior cingulate cortex (ACC) are thought to be involved in the pathophysiology of bipolar disorder, but structural Magnetic Resonance Imaging (MRI) studies have reported variable findings. Reasons for this include a failure to consider variability in regional cortical folding patterns and a reliance on relatively coarse measures (e.g., volume) to index anatomical change. We sought to overcome these limitations by combining a novel protocol for parcellating the ACC and adjacent paracingulate cortex (PaC) that accounts for inter-individual variations in sulcal and gyral morphology with a cortical surface-based approach that allowed calculation of regional grey matter volume, surface area and cortical thickness in 24 patients with bipolar I disorder and 24 matched controls. No changes in grey matter volume or surface area were identified in any region, but patients did show significant reductions in cortical thickness in the left rostral PaC and right dorsal PaC that were not attributable to group differences in cortical folding patterns. These findings suggest that bipolar disorder is associated with more pronounced changes in the PaC, and that reliance on volumetric measures alone may obscure more subtle differences. © 2007.

Details

Title: Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorder
Authors: A Fornito (Author) - University of Sydney
G S Malhi (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
B Ivanovski (Author) - University of Sydney
S J Wood (Author) - University of Sydney
M M Saling (Author) - University of Sydney
C Pantelis (Author) - University of Sydney
M Yücel (Author) - University of Sydney
Publication details: Psychiatry Research: Neuroimaging, Vol.162(2), pp.123-132
Publisher: Elsevier Ireland Ltd.
Date published: 2008
DOI: 10.1016/j.pscychresns.2007.06.004
ISSN: 0925-4927
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449156002621
Output Type: Journal article

Metrics

480 Record Views

71 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Web Of Science research areas: Clinical Neurology; Neuroimaging; Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites