Journal article
Analysis of GABA: Receptor subunit genes in multiplex pedigrees with manic depression
Psychiatric Genetics, Vol.4(3), pp.185-191
1994
Abstract
The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of manic depression. Tests of this hypothesis can now be carried out due to the recent characterization of simple sequence repeat polymorphisms for the GABA A receptor Α1, Α2, Α4, Α5, Α6, Î’1, Î’3 and Γ2 subunit genes. Using both parametric and non-parametric methods, we tested for linkage between manic depression and these polymorphisms in six multi-generational pedigrees. No evidence of linkage was found. © 1994 Rapid Communications of Oxford Ltd.
Details
- Title
- Analysis of GABA: Receptor subunit genes in multiplex pedigrees with manic depression
- Authors
- H Coon (Author)A A Hicks (Author)M E S Bailey (Author)M Hoff (Author)J Holik (Author)Robert J Harvey (Author)K J Johnson (Author)M G Darlison (Author)F Reimherr (Author)P Wender (Author)W Byerley (Author)
- Publication details
- Psychiatric Genetics, Vol.4(3), pp.185-191
- Publisher
- Lippincott Williams & Wilkins
- Date published
- 1994
- DOI
- 10.1097/00041444-199400430-00009
- ISSN
- 0955-8829
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450315102621
- Output Type
- Journal article
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