An unusual kynurenine‐containing opioid tetrapeptide from the skin gland secretion of the Australian red tree frog Litoria rubella. Sequence determination by electrospray mass spectrometry

S T Ellis-Steinborner; D Scanlon; I F Musgrave; T T Nha Tran; S Hack; Tianfang Wang; A D Abell; M J Tyler; J H Bowie

doi:10.1002/rcm.5041

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An unusual kynurenine‐containing opioid tetrapeptide from the skin gland secretion of the Australian red tree frog Litoria rubella. Sequence determination by electrospray mass spectrometry

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Peer reviewed

An unusual kynurenine‐containing opioid tetrapeptide from the skin gland secretion of the Australian red tree frog Litoria rubella. Sequence determination by electrospray mass spectrometry

S T Ellis-Steinborner, D Scanlon, I F Musgrave, T T Nha Tran, S Hack, Tianfang Wang, A D Abell, M J Tyler and J H Bowie

Rapid Communications in Mass Spectrometry, Vol.25(12), pp.1735-1740

2011

DOI: https://doi.org/10.1002/rcm.5041

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Abstract

The Kyn-containing peptide FP-Kyn-L(NH2) is an unusual minor component of the skin peptide profile of the Australian red tree frog Litoria rubella collected from an area within a 20 kilometre radius of Alice Springs in central Australia. The structure was determined by electrospray mass spectrometry and synthesis. The major component of the skin secretion is the analogous tryptophyllin peptide FPWL(NH2). Both peptides show opioid activity at 10-7M, and are likely to act via the μ opioid receptor.

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Title: An unusual kynurenine‐containing opioid tetrapeptide from the skin gland secretion of the Australian red tree frog Litoria rubella. Sequence determination by electrospray mass spectrometry
Authors: S T Ellis-Steinborner (Author) - University of Adelaide
D Scanlon (Author) - University of Adelaide
I F Musgrave (Author) - University of Adelaide
T T Nha Tran (Author) - University of Adelaide
S Hack (Author) - University of Adelaide
Tianfang Wang (Author) - University of Adelaide
A D Abell (Author) - University of Adelaide
M J Tyler (Author) - University of Adelaide
J H Bowie (Author) - University of Adelaide
Publication details: Rapid Communications in Mass Spectrometry, Vol.25(12), pp.1735-1740
Publisher: John Wiley & Sons Ltd.
Date published: 2011
DOI: 10.1002/rcm.5041
ISSN: 0951-4198
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450165202621
Output Type: Journal article

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