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Published VersionCC BY V4.0, Open Access
Journal article
An overview of microneedle applications, materials, and fabrication methods
Beilstein Journal of Nanotechnology, Vol.12(1), pp.1034-1046
2021
PMCID: PMC8450954
PMID: 34621614
Abstract
Microneedle-based microdevices promise to expand the scope for delivery of vaccines and therapeutic agents through the skin and withdrawing biofluids for point-of-care diagnostics – so-called theranostics. Unskilled and painless applications of microneedle patches for blood collection or drug delivery are two of the advantages of microneedle arrays over hypodermic needles. Developing the necessary microneedle fabrication processes has the potential to dramatically impact the health care delivery system by changing the landscape of fluid sampling and subcutaneous drug delivery. Microneedle designs which range from sub-micron to millimetre feature sizes are fabricated using the tools of the microelectronics industry from metals, silicon, and polymers. Various types of subtractive and additive manufacturing processes have been used to manufacture microneedles, but the development of microneedle-based systems using conventional subtractive methods has been constrained by the limitations and high cost of microfabrication technology. Additive manufacturing processes such as 3D printing and two-photon polymerization fabrication are promising transformative technologies developed in recent years. The present article provides an overview of microneedle systems applications, designs, material selection, and manufacturing methods.
Details
- Title
- An overview of microneedle applications, materials, and fabrication methods
- Authors
- Zahra Faraji Rad - University of Southern QueenslandPhilip D Prewett (Corresponding Author) - University of BirminghamGraham J Davies - University of Birmingham
- Publication details
- Beilstein Journal of Nanotechnology, Vol.12(1), pp.1034-1046
- Publisher
- Beilstein - Institut zur Foerderung der Chemischen Wissenschaften
- Date published
- 2021
- DOI
- 10.3762/bjnano.12.77
- ISSN
- 2190-4286
- PMID
- 34621614; PMC8450954
- Copyright note
- This is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 991140305902621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied
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Source: InCites