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Vox Sanguinis - 2024 - Faddy - An international review of the characteristics of viral nucleic acid‐amplification testing 1.76 MB
Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
An international review of the characteristics of viral nucleic acid-amplification testing (NAT) reveals a trend towards the use of smaller pool sizes and individual donation NAT
Vox Sanguinis, Vol.119(7), pp.745-751
2024
PMID: 38516962
Appears in UniSC Supported Open Access Outputs
Abstract
Background and Objectives
Nucleic acid-amplification testing (NAT) is used for screening blood donations/donors for blood-borne viruses. We reviewed global viral NAT characteristics and NAT-yield confirmatory testing used by blood operators.
Materials and Methods
NAT characteristics and NAT-yield confirmatory testing used during 2019 was surveyed internationally by the International Society of Blood Transfusion Working Party Transfusion-Transmitted Infectious Diseases. Reported characteristics are presented herein.
Results
NAT was mainly performed under government mandate. Human immunodeficiency virus (HIV), hepatitis C virus (HCV) and hepatitis B virus (HBV) NAT was performed on all donors and donation types, while selective testing was reported for West Nile virus, hepatitis E virus (HEV), and Zika virus. Individual donation NAT was used for HIV, HCV and HBV by ~50% of responders, while HEV was screened in mini-pools by 83% of responders performing HEV NAT. Confirmatory testing for NAT-yield samples was generally performed by NAT on a sample from the same donation or by NAT and serology on samples from the same donation and a follow-up sample.
Conclusion
In the last decade, there has been a trend towards use of smaller pool sizes or individual donation NAT. We captured characteristics of NAT internationally in 2019 and provide insights into confirmatory testing approaches used for NAT-yields, potentially benefitting blood operators seeking to implement NAT.
Details
- Title
- An international review of the characteristics of viral nucleic acid-amplification testing (NAT) reveals a trend towards the use of smaller pool sizes and individual donation NAT
- Authors
- Helen M Faddy (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health - BiomedicineCarla Osiowy - Public Health Agency of CanadaBrian Custer - VitalantMichael Busch - VitalantSusan L StramerMelinda M Dean - University of the Sunshine Coast, Queensland, School of Health - BiomedicineJessika Acutt - University of the Sunshine Coast, Queensland, UniSC Clinical Trials CentreElvina Viennet - Australian Red Cross LifebloodThijs van de Laar - SanquinWai-Chiu Tsoi - Hong Kong Red CrossClaire Styles - Australian Red Cross LifebloodPhil Kiely - Australian Red Cross LifebloodAngelo Margaritis - Australian Red Cross LifebloodSo-Yong Kwon - Korean Red CrossYan Qiu - Beijing Red Cross Blood CenterXuelian Deng - Dalian Blood Centre (China, Dalian)Antoine Lewin - Héma-QuébecSigne Winther Jørgensen - Aarhus University HospitalChristian Erikstrup - Aarhus University HospitalDavid Juhl - University Hospital Schleswig-HolsteinSilvia Sauleda - Banc de Sang i TeixitsBernardo Armando Camacho Rodriguez - Institute of Biotechnology Science and Health Innovation (Columbia)Lisbeth Jennifer Catherine Soto Coral - Institute of Biotechnology Science and Health Innovation (Columbia)Paula Andrea Gaviria García - Institute of Biotechnology Science and Health Innovation (Columbia)Sineenart Oota - Thai Red Cross SocietySheila F O'Brien - Canadian Blood ServicesSilvano Wendel - Hospital Sírio-LibanêsEmma Castro - Centre de Transfusió de la Comunitat Valenciana (Spain)Laura Navarro Pérez - Centre de Transfusió de la Comunitat Valenciana (Spain)Heli Harvala - NHS Blood and TransplantKaty Davison - NHS Blood and TransplantClaire Reynolds - NHS Blood and TransplantLisa Jarvis - Scottish National Blood Transfusion ServicePiotr Grabarczyk - Instytut Hematologii i TransfuzjologiAneta Kopacz - Instytut Hematologii i TransfuzjologiMagdalena Łętowska - Instytut Hematologii i TransfuzjologiNiamh O'Flaherty - Irish Blood Transfusion ServiceFiona Young - Irish Blood Transfusion ServicePadraig Williams - Irish Blood Transfusion ServiceLisa Burke - Irish Blood Transfusion ServiceSze Sze Chua - Health Sciences AuthorityAn Muylaert - Belgian Red CrossIsabel Page - Centro Regional de HemodonaciónAnn Jones - Welsh Blood Service (Wales, Pontyclun)Christoph Niederhauser - Swiss Red CrossMarion Vermeulen - South African National Blood ServiceSyria Laperche - Établissement Français du SangPierre Gallian - Établissement Français du SangMasahiro Satake - Japanese Red Cross Society, JapanMarcelo Addas-Carvalho - Universidade Estadual de Campinas (UNICAMP)Sebastián Blanco - Central Blood Bank Foundation (Argentina)Sandra V Gallego - Universidad Nacional de CórdobaAxel Seltsam - German Red CrossMarijke Weber-Schehl - German Red CrossArwa Z Al-Riyami - Sultan Qaboos University HospitalKhuloud Al Maamari - Sultan Qaboos University HospitalFatma Ba Alawi - Sultan Qaboos University HospitalHem Chandra Pandey - All India Institute of Medical SciencesRochele Azevedo França - Clinics Hospital of Ribeirão PretoRichard Charlewood - New Zealand Blood Service, Auckland, New ZealandVirology and Surveillance, Risk Assessment and Policy subgroups of the ISBT WP‐TTID
- Publication details
- Vox Sanguinis, Vol.119(7), pp.745-751
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2024
- DOI
- 10.1111/vox.13617
- ISSN
- 1423-0410; 0042-9007
- PMID
- 38516962
- Copyright note
- © 2024 The Authors. Vox Sanguinis published by John Wiley & Sons Ltd on behalf of International Society of Blood Transfusion. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Data Availability
- The data that support the findings of this study are available from the corresponding author upon reasonable request.
- Organisation Unit
- School of Health - Biomedicine; School of Health; UniSC Clinical Trials Centre
- Language
- English
- Record Identifier
- 991011197202621
- Output Type
- Journal article
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- Industry collaboration
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- Hematology
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