Journal article
An exploratory study to assess the activity of the acarine growth inhibitor, fluazuron, against Sarcoptes scabei infestation in pigs
Parasites & vectors, Vol.5, 40
2012
Abstract
The most common treatments for scabies in human and veterinary settings are topical 5% permethrin or systemic treatment with ivermectin. However, these treatments have very little activity against arthropod eggs, and therefore repeated treatment is frequently required. In-vitro, biochemical and molecular studies have demonstrated that human mites are becoming increasingly resistant to both acaricides. To identify alternate acaricides, we undertook a pilot study of the in vivo activity of the benzoylphenyl urea inhibitor of chitin synthesis, fluazuron, in pigs with sarcoptic mange. Findings: Pigs (n=5) were infested with S. scabei var suis, and randomised to treatment at the start of peak infestation with fluazuron at a dose of 10mg/kg/day per os for 7 days (n=3) or no treatment (n=2). Clinical scores, skin scrapings for mite counts and blood sampling for pharmacokinetic analysis were undertaken. Fluazuron was well absorbed in treated pigs with measureable blood levels up to 4 weeks post treatment. No adverse effects were observed. Modest acaricidal activity of the compound was observed, with a reduction in severity of skin lesions in treated pigs, as well as a reduction in number of scabies mite's early life stages.
Details
- Title
- An exploratory study to assess the activity of the acarine growth inhibitor, fluazuron, against Sarcoptes scabei infestation in pigs
- Authors
- C J Pasay (Author) - Queensland Institute of Medical ResearchJ Rothwell (Author) - University of QueenslandKate E Mounsey (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringA Kelly (Author) - University of QueenslandB Hutchinson (Author) - University of QueenslandA Miezler (Author) - University of QueenslandJ S McCarthy (Author) - Queensland Institute of Medical Research
- Publication details
- Parasites & vectors, Vol.5, 40
- Publisher
- BioMed Central Ltd.
- Date published
- 2012
- DOI
- 10.1186/1756-3305-5-40
- ISSN
- 1756-3305
- Copyright note
- Copyright © 2012 Pasay et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This published version is reproduced here in accordance with this policy.
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99449621602621
- Output Type
- Journal article
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