An emotional Stroop functional MRI study of euthymic bipolar disorder

G S Malhi; Jim Lagopoulos; P S Sachdev; B Ivanovski; R Shnier

doi:10.1111/j.1399-5618.2005.00255.x

Back

An emotional Stroop functional MRI study of euthymic bipolar disorder

Journal article

Peer reviewed

An emotional Stroop functional MRI study of euthymic bipolar disorder

G S Malhi, Jim Lagopoulos, P S Sachdev, B Ivanovski and R Shnier

Bipolar Disorders, Vol.7(Supplement 5), pp.58-69

2005

DOI: https://doi.org/10.1111/j.1399-5618.2005.00255.x

Files and links (1)

url

https://doi.org/10.1111/j.1399-5618.2005.00255.xView

Published Version

Abstract

affective

bipolar disorder

euthymia

fMRI

mood induction

Stroop

Objective: To identify the brain regions associated with emotional processing in euthymic bipolar patients. Methods: The study examined 12 euthymic bipolar patients using functional magnetic resonance imaging (fMRI) while performing an emotional Stroop (eStroop) task. The task comprised emotionally valent and neutral words presented in alternating blocks that was designed to implicitly induce affect. In conjunction with fMRI, galvanic skin responses (GSR) were measured to monitor arousal. Results: Euthymic bipolar patients had diminished activation in response to the affective stimuli in both cortical and subcortical brain regions when compared with healthy subjects. In particular, patients had less activation in the left ventral prefrontal cortex suggesting a potential trait deficit. Patients were slower to react than healthy controls, but did not differ with respect to accuracy. Conclusions: Euthymic bipolar patients are perhaps constrained in their ability to engage affective processing. Diminished ventral prefrontal cortex activation corroborates previous reports of a potential trait deficit, suggesting that 'all is not well in euthymia', although the effects of medication cannot be overlooked. © Blackwell Munksgaard, 2005.

Details

Title: An emotional Stroop functional MRI study of euthymic bipolar disorder
Authors: G S Malhi (Author) - University of New South Wales
Jim Lagopoulos (Author) - University of New South Wales
P S Sachdev (Author) - University of New South Wales
B Ivanovski (Author) - University of New South Wales
R Shnier (Author) - Mayne Group
Publication details: Bipolar Disorders, Vol.7(Supplement 5), pp.58-69
Publisher: Wiley-Blackwell Publishing Inc.
Date published: 2005
DOI: 10.1111/j.1399-5618.2005.00255.x
ISSN: 1398-5647
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449313102621
Output Type: Journal article

Metrics

544 Record Views

150 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences; Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites