Journal article
An Autosomal Linkage Scan for Cannabis Use Disorders in the Nicotine Addiction Genetics Project
Archives of General Psychiatry, Vol.65(6), pp.713-721
2008
Abstract
Context: Despite accumulating evidence that there is a genetic basis for cannabis use disorders (ie, abuse and dependence), few studies have identified genomic regions that may harbor biological risk and protective factors. Objective: To conduct autosomal linkage analyses that identify genomic regions that may harbor genes conferring a vulnerability to cannabis use disorders. Design: In 289 Australian families who participated in the Nicotine Addiction Genetics Project, 423 autosomal markers were genotyped. Families were ascertained for heavy cigarette smoking. Linkage was conducted for DSM-IV cannabis dependence and for a novel factor score representing problems with cannabis use, including occurrence of 3 of 4 abuse criteria (excluding legal problems) and 6 DSM-IV dependence criteria. Results: A maximum logarithm of odds (LOD) of 3.36 was noted for the cannabis problems factor score on chromosome arm 1p. An LOD of 2.2 was noted on chromosome 4 in the region of the -aminobutyric acid type A gene cluster, including GABRA2, which has been implicated in drug use disorders. For DSM-IV cannabis dependence, a modest LOD score on chromosome 6 (1.42) near cannabinoid receptor 1 (CNR1) was identified. In addition, support for an elevation on chromosome 3, identified in prior independent studies, was noted for the factor score and cannabis dependence (LOD, 1.4). Conclusions: Genes such as ELTD1 on chromosome 1, in addition to genes on chromosomes 4 (eg, GABRA2) and 6 (eg, CNR1), may be associated with the genetic risk for cannabis use disorders. We introduce a novel quantitative phenotype, a cannabis problems factor score composed of DSM-IV abuse and dependence criteria, that may be useful for future linkage and association studies.
Details
- Title
- An Autosomal Linkage Scan for Cannabis Use Disorders in the Nicotine Addiction Genetics Project
- Authors
- A Agrawal (Author) - Washington University, United StatesM L Pergadia (Author) - Washington University, United StatesS F Saccone (Author) - Washington University, United StatesM T Lynskey (Author) - Washington University, United StatesJ C Wang (Author) - Washington University, United StatesN G Martin (Author) - Queensland Institute of Medical ResearchDixie J Statham (Author) - Queensland Institute of Medical ResearchA Henders (Author) - Queensland Institute of Medical ResearchM Campbell (Author) - Queensland Institute of Medical ResearchR Garcia (Author) - Washington University, United StatesU Broms (Author) - University of Helsinki, FinlandR D Todd (Author) - Washington University, United StatesA M Goate (Author) - Washington University, United StatesJ Rice (Author) - Washington University, United StatesJ Kaprio (Author) - University of Helsinki, FinlandA C Heath (Author) - Washington University, United StatesG W Montgomery (Author) - Queensland Institute of Medical ResearchP A F Madden (Author) - Washington University, United States
- Publication details
- Archives of General Psychiatry, Vol.65(6), pp.713-721
- Publisher
- American Medical Association
- Date published
- 2008
- DOI
- 10.1001/archpsyc.65.6.713
- ISSN
- 0003-990X
- Organisation Unit
- School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99449761202621
- Output Type
- Journal article
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