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Amygdala cannulation alters expression of cocaine conditioned place preference and locomotion in rats
Journal article   Peer reviewed

Amygdala cannulation alters expression of cocaine conditioned place preference and locomotion in rats

Volker Herzig and W J Schmidt
Addiction Biology, Vol.12(3-4), pp.478-481
2007
url
https://doi.org/10.1111/j.1369-1600.2007.00060.xView
Published Version

Abstract

Amygdala cannulation effect cocaine conditioned place preference expression locomotion microinfusion
The effect of transient inactivation of the amygdala on expression of cocaine conditioned place preference (CPP) and locomotion was studied. We found that rats with bilateral but not unilateral amygdala cannula placement exhibited increased CPP expression during a vehicle and a cocaine test as well as increased cocaine-induced hyper-locomotion. We discuss the observed effects as being caused by the cannulation per se and we conclude that the applied cannulation produced an increased responsiveness of the amygdala by a yet undetermined mechanism.

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Biochemistry & Molecular Biology
Substance Abuse

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