Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium

Emily L Dennis; Seth G Disner; Negar Fani; Lauren E Salminen; Mark Logue; Emily K Clarke; Courtney C Haswell; Christopher L Averill; Lee A Baugh; Jessica Bomyea; Steven E Bruce; Jiook Cha; Kyle Choi; Nicholas D Davenport; Maria Densmore; Stefan du Plessis; Gina L Forster; Jessie L Frijling; Atilla Gonenc; Daniel W Grupe; Staci Gruber; Jeffrey P Guenette; Jasmeet Hayes; David Hofmann; Jonathan Ipser; Tanja Jovanovic; Sinead Kelly; Mitzy Kennis; Philipp Kinzel; Saskia B J Koch; Inga Koerte; Sheri Koopowitz; Mayuresh Korgaonkar; John Krystal; Lauren A M Lebois; Gen Li; Vincent A Magnotta; Antje Manthey; Geoff J May; Laura Nawijn; Deleene S Menefee; Steven M Nelson; Richard W J Neufeld; Jack B Nitschke; Daniel O'Doherty; Matthew Peverill; Kerry J Ressler; Annerine Roos; Margaret A Sheridan; Anika Sierk; Alan Simmons; Raluca M Simons; Jeffrey S Simons; Jennifer Stevens; Benjamin Suarez-Jimenez; Danielle R Sullivan; Jean Théberge; Jana K Tran; Leigh van den Heuvel; Steven J A van der Werff; Sanne J H van Rooij; Mirjam van Zuiden; Carmen Velez; Mieke Verfaellie; Robert R J M Vermeiren; Benjamin S C Wade; Tor Wager; Henrik Walter; Sherry Winternitz; Jonathan Wolff; Gerald York; Ye Zhu; Xi Zhu; Chadi G Abdallah; Richard Bryant; Judith K Daniels; Richard J Davidson; Kelene A Fercho; Carol Franz; Elbert Geuze; Evan M Gordon; Milissa L Kaufman; William S Kremen; Jim Lagopoulos; Ruth A Lanius; Michael J Lyons; Stephen R McCauley; Regina McGlinchey; Katie A McLaughlin; William Milberg; Yuval Neria; Miranda Olff; Soraya Seedat; Martha Shenton; Scott R Sponheim; Dan J Stein; Murray B Stein; Thomas Straube; David F Tate; Dick J Veltman; Nic J A van der Wee; Li Wang; Elisabeth A Wilde; Paul M Thompson; Peter Kochunov; Neda Jahanshad; Rajendra A Morey

doi:10.1038/s41380-019-0631-x

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Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium

Journal article

Peer reviewed

Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium

Emily L Dennis, Seth G Disner, Negar Fani, Lauren E Salminen, Mark Logue, Emily K Clarke, Courtney C Haswell, Christopher L Averill, Lee A Baugh, Jessica Bomyea, …

Molecular Psychiatry, Vol.26(8), pp.4315-4330

2019

DOI: https://doi.org/10.1038/s41380-019-0631-x

PMCID: PMC7302988

PMID: 31857689

Appears in UniSC Diversity and Inclusion Research Collection

Abstract

UniSC Diversity Area - Disability and Inclusion

A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed, which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3,047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1,426 individuals with PTSD and 1,621 controls (2174 males/873 females) between ages 18–83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen’s d=−0.11, p=0.0055). The tapetum connects the left and right hippocampus, structures for which structure and function have been consistently implicated in PTSD. Results remained significant/similar after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.

Details

Title: Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium
Authors: Emily L Dennis (Corresponding Author) - University of Utah
Seth G Disner (Author) - University of Minnesota
Negar Fani (Author) - Emory University School of Medicine
Lauren E Salminen (Author) - University of Southern California
Mark Logue (Author) - Boston University School of Medicine
Emily K Clarke (Author) - Duke University
Courtney C Haswell (Author) - Duke University
Christopher L Averill (Author) - Yale University
Lee A Baugh (Author) - University of South Dakota
Jessica Bomyea (Author) - University of California, San Diego
Steven E Bruce (Author) - University of Missouri–St. Louis
Jiook Cha (Author) - Columbia University Irving Medical Center
Kyle Choi (Author) - University of California, San Diego
Nicholas D Davenport (Author) - University of Minnesota
Maria Densmore (Author) - University of Western Ontario
Stefan du Plessis (Author) - Stellenbosch University
Gina L Forster (Author) - University of South Dakota
Jessie L Frijling (Author) - University of Amsterdam
Atilla Gonenc (Author) - Harvard Medical School
Daniel W Grupe (Author) - University of Wisconsin–Madison
Staci Gruber (Author) - Harvard Medical School
Jeffrey P Guenette (Author) - Brigham and Women's Hospital
Jasmeet Hayes (Author) - The Ohio State University
David Hofmann (Author) - University of Münster
Jonathan Ipser (Author) - University of Cape Town
Tanja Jovanovic (Author) - Wayne State University
Sinead Kelly (Author) - Harvard Medical School
Mitzy Kennis (Author) - Utrecht University
Philipp Kinzel (Author) - Brigham and Women's Hospital
Saskia B J Koch (Author) - University of Amsterdam
Inga Koerte (Author) - Ludwig Maximilian University of Munich
Sheri Koopowitz (Author) - University of Cape Town
Mayuresh Korgaonkar (Author) - University of Sydney
John Krystal (Author) - Yale University
Lauren A M Lebois (Author) - Harvard Medical School
Gen Li (Author) - Chinese Academy of Sciences
Vincent A Magnotta (Author) - University of Iowa
Antje Manthey (Author) - Charité - Universitätsmedizin Berlin
Geoff J May (Author) - The University of Texas at Dallas
Laura Nawijn (Author) - University of Amsterdam
Deleene S Menefee (Author) - Baylor College of Medicine
Steven M Nelson (Author) - Baylor University
Richard W J Neufeld (Author) - University of British Columbia
Jack B Nitschke (Author) - University of Wisconsin–Madison
Daniel O'Doherty (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Matthew Peverill (Author) - University of Washington
Kerry J Ressler (Author) - Radboud University Nijmegen
Annerine Roos (Author) - Stellenbosch University
Margaret A Sheridan (Author) - University of North Carolina at Chapel Hill
Anika Sierk (Author) - Charité - Universitätsmedizin Berlin
Alan Simmons (Author) - University of California, San Diego
Raluca M Simons (Author) - University of South Dakota
Jeffrey S Simons (Author) - University of South Dakota
Jennifer Stevens (Author) - Emory University School of Medicine
Benjamin Suarez-Jimenez (Author) - Columbia University Irving Medical Center
Danielle R Sullivan (Author) - Boston University School of Medicine
Jean Théberge (Author) - University of Western Ontario
Jana K Tran (Author) - Houston Fire Department (Houston, USA)-HFD
Leigh van den Heuvel (Author) - Stellenbosch University
Steven J A van der Werff (Author) - Leiden University Medical Center
Sanne J H van Rooij (Author) - Emory University School of Medicine
Mirjam van Zuiden (Author) - University of Amsterdam
Carmen Velez (Author) - University of Utah
Mieke Verfaellie (Author) - Boston University School of Medicine
Robert R J M Vermeiren (Author) - Leiden University Medical Center
Benjamin S C Wade (Author) - University of Utah
Tor Wager (Author) - Dartmouth College
Henrik Walter (Author) - Charité
Sherry Winternitz (Author) - Harvard Medical School
Jonathan Wolff (Author) - McLean Hospital
Gerald York (Author) - Alaska Radiology Associates (United States)
Ye Zhu (Author) - Chinese Academy of Sciences
Xi Zhu (Author) - Columbia University
Chadi G Abdallah (Author) - Yale University
Richard Bryant (Author) - UNSW Australia
Judith K Daniels (Author) - University of Groningen
Richard J Davidson (Author) - University of Wisconsin–Madison
Kelene A Fercho (Author) - University of South Dakota
Carol Franz (Author) - University of California, San Diego
Elbert Geuze (Author) - Utrecht University
Evan M Gordon (Author) - Baylor University
Milissa L Kaufman (Author) - Harvard Medical School
William S Kremen (Author) - University of California, San Diego
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Ruth A Lanius (Author) - University of Western Ontario
Michael J Lyons (Author) - Boston University School of Medicine
Stephen R McCauley (Author) - Baylor College of Medicine
Regina McGlinchey (Author) - Harvard Medical School
Katie A McLaughlin (Author) - Harvard University
William Milberg (Author) - Harvard Medical School
Yuval Neria (Author) - Columbia University Irving Medical Center
Miranda Olff (Author) - University of Amsterdam
Soraya Seedat (Author) - Stellenbosch University
Martha Shenton (Author) - Brigham and Women's Hospital
Scott R Sponheim (Author) - University of Minnesota
Dan J Stein (Author) - University of Cape Town
Murray B Stein (Author) - University of California, San Diego
Thomas Straube (Author) - University of Münster
David F Tate (Author) - University of Utah
Dick J Veltman (Author) - Amsterdam UMC Location VUmc
Nic J A van der Wee (Author) - Leiden University Medical Center
Li Wang (Author) - Chinese Academy of Sciences
Elisabeth A Wilde (Author) - University of Utah
Paul M Thompson (Author) - University of Southern California
Peter Kochunov (Author) - University of Maryland, Baltimore County
Neda Jahanshad (Author) - University of Southern California
Rajendra A Morey (Author) - Duke University
Publication details: Molecular Psychiatry, Vol.26(8), pp.4315-4330
Publisher: Nature Publishing Group
Date published: 2019
DOI: 10.1038/s41380-019-0631-x
ISSN: 1476-5578
PMID: 31857689; PMC7302988
Organisation Unit: Thompson Institute
Language: English
Record Identifier: 99523107402621
Output Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Neurosciences; Psychiatry

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