Altered bone and body composition in children and adolescents with confirmed prenatal alcohol exposure

Sophia L. Young; Linda A. Gallo; Denise S.K. Brookes; Nicole Hayes; Maree Maloney; Karen Liddle; Amanda James; Karen M. Moritz; Natasha Reid

doi:10.1016/j.bone.2022.116510

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Altered bone and body composition in children and adolescents with confirmed prenatal alcohol exposure

Journal article

Peer reviewed

Altered bone and body composition in children and adolescents with confirmed prenatal alcohol exposure

Sophia L. Young, Linda A. Gallo, Denise S.K. Brookes, Nicole Hayes, Maree Maloney, Karen Liddle, Amanda James, Karen M. Moritz and Natasha Reid

Bone, Vol.164, pp.1-8

2022

DOI: https://doi.org/10.1016/j.bone.2022.116510

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Abstract

Bone mineral density

Dual X-ray absorptiometry

Fetal alcohol spectrum disorder

Lean tissue mass

Paediatric growth

Prenatal alcohol

Prenatal alcohol exposure can contribute to long term adverse health outcomes. Development of the skeletal system begins at the early embryonic stage and continues into early adulthood but the effect of prenatal alcohol exposure on skeletal growth is relatively unexplored in a clinical population. Here, we performed dual X-ray absorptiometry to examine bone, fat, and muscle accrual in children and adolescents diagnosed with, or at risk of, fetal alcohol spectrum disorders (FASDs). Children (aged 4–9 years) with FASD or at risk of FASD (n = 10) had similar growth to age matched controls (n = 27). By adolescence (aged ≥10 years), those with FASDs (n = 13) were shorter and had lower areal bone mineral density and lean tissue mass than typically developing peers (n = 29). Overall, adolescents diagnosed with FASDs had greater odds of impairments to bone and body composition. These findings highlight the importance of early FASD diagnosis and appropriate post-diagnostic medical follow-up to enable timely, effective interventions to optimize bone and body composition during paediatric growth. [Display omitted] •Children with/at risk of FASDs had similar growth to control group.•Adolescents with FASDs had lower bone mineral density than the control group.•Findings highlight importance of early diagnosis of FASDs.

Details

Title: Altered bone and body composition in children and adolescents with confirmed prenatal alcohol exposure
Authors: Sophia L. Young (Author) - University of Queensland
Linda A. Gallo (Author) - University of Queensland
Denise S.K. Brookes (Author) - Institute of Health and Biomedical Innovation, Centre for Children's Health Research, South Brisbane, Australia
Nicole Hayes (Author) - Child Health Research Centre, Centre for Children's Health Research, South Brisbane, Australia
Maree Maloney (Author) - School of Health and Rehabilitation Sciences, University of Queensland, St Lucia, Australia
Karen Liddle (Author) - Queensland Health
Amanda James (Author) - Queensland Children’s Hospital
Karen M. Moritz (Author) - University of Queensland
Natasha Reid (Author) - University of Queensland
Publication details: Bone, Vol.164, pp.1-8
Publisher: Elsevier Inc.
DOI: 10.1016/j.bone.2022.116510
ISSN: 1873-2763
Organisation Unit: School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99679195302621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Endocrinology & Metabolism

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