Journal article
Altered Motor and Motor Perceptual Cognitive Imagery Task–Related Activation in Diabetic Peripheral Neuropathy: Insights From Functional MRI
Diabetes Care, Vol.42(10), pp.2004-2007
2019
PMID: 31530664
Abstract
OBJECTIVE: To compare central nervous system (CNS) activation in patients with and without diabetic peripheral neuropathy (DPN) during motor and motor imagery tasks and to correlate activation with functional performance. RESEARCH DESIGN AND METHODS: Twenty-six participants (13 with DPN, 13 without DPN) underwent functional MRI during three tasks: ankle dorsi plantar flexion (motor task [MT]) and motor imagery tasks of walking on a smooth surface (SMIT) and rough surface (RMIT). Functional assessment included gait analysis, ankle muscle strength, and ankle range of motion. RESULTS: The tasks activated the sensorimotor, motor preparation, visual processing, and decision-making regions. Activation was significantly lower in patients with DPN than in those without DPN during MT and SMIT but not RMIT. Poor functional performance in patients with DPN was associated with greater activation in motor preparation regions. CONCLUSIONS: In patients with DPN, CNS responses appear muted compared with patients without DPN, but they remain capable of enhancing CNS activation when tasks are more challenging or when functional deficits are substantial. Functional deficits, including impaired balance, altered gait, and a higher risk of falls, are key consequences of diabetic peripheral neuropathy (DPN) (1); however, central nervous system (CNS) responses that compensate or contribute to these deficits have not yet been studied. Emerging evidence suggests that DPN may also involve alterations in the CNS (2–5); therefore, we examined CNS activation in patients with DPN during motor and motor perceptual cognitive imagery tasks compared with patients without DPN and correlated activation patterns to functional performance outside the scanner.
Details
- Title
- Altered Motor and Motor Perceptual Cognitive Imagery Task–Related Activation in Diabetic Peripheral Neuropathy: Insights From Functional MRI
- Authors
- Kavita Venkataraman (Author) - National University of SingaporeVivian Pun (Author) - National University of SingaporeAbdalla Z Mohamed (Author) - University of QueenslandMiyang Luo (Author) - National University of SingaporeCaroline Wong (Author) - National University of SingaporeFangrong Zong (Author) - University of QueenslandEric Y.H Khoo (Author) - National University of SingaporeE. Shyong Tai (Author) - National University of SingaporeFatima A Nasrallah (Author) - University of Queensland
- Publication details
- Diabetes Care, Vol.42(10), pp.2004-2007
- Publisher
- American Diabetes Association
- DOI
- 10.2337/dc19-0746
- ISSN
- 1935-5548
- PMID
- 31530664
- Organisation Unit
- Thompson Institute; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99522404202621
- Output Type
- Journal article
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- Endocrinology & Metabolism
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