Alterations in white matter network topology contribute to freezing of gait in Parkinson’s disease

J M Hall; J M Shine; K A Ehgoetz Martens; M Gilat; Kathryn Broadhouse; J Y Y Szeto; C C Walton; A A Moustafa; S J G Lewis

doi:10.1007/s00415-018-8846-3

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Alterations in white matter network topology contribute to freezing of gait in Parkinson’s disease

Journal article

Peer reviewed

Alterations in white matter network topology contribute to freezing of gait in Parkinson’s disease

J M Hall, J M Shine, K A Ehgoetz Martens, M Gilat, Kathryn Broadhouse, J Y Y Szeto, C C Walton, A A Moustafa and S J G Lewis

Journal of Neurology, Vol.265(6), pp.1353-1364

2018

DOI: https://doi.org/10.1007/s00415-018-8846-3

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Abstract

Parkinson's disease

freezing of gait

connectome

difusion imaging

Freezing of gait (FOG) is a common symptom in advanced Parkinson's disease (PD). Despite current advances, the neural mechanisms underpinning this disturbance remain poorly understood. To this end, we investigated the structural organisation of the white matter connectome in PD freezers and PD non-freezers. We hypothesized that freezers would show an altered network architecture, which could hinder the effective information processing that characterizes the disorder. Twenty-six freezers and twenty-four well-matched non-freezers were included in this study. Using diffusion tensor imaging, we investigated the modularity and integration of the regional connectome by calculating the module degree z score and the participation coefficient, respectively. Compared to non-freezers, freezers demonstrated lower participation coefficients in the right caudate, thalamus, and hippocampus, as well as within superior frontal and parietal cortical regions. Importantly, several of these nodes were found within the brain's 'rich club'. Furthermore, group differences in module degree z scores within cortical frontal and sensory processing areas were found. Together, our results suggest that changes in the structural network topology contribute to the manifestation of FOG in PD, specifically due to a lack of structural integration between key information processing hubs of the brain.

Details

Title: Alterations in white matter network topology contribute to freezing of gait in Parkinson’s disease
Authors: J M Hall (Author) - University of Sydney
J M Shine (Author) - University of Sydney
K A Ehgoetz Martens (Author) - University of Sydney
M Gilat (Author) - University of Sydney
Kathryn Broadhouse (Author) - University of Sydney
J Y Y Szeto (Author) - University of Sydney
C C Walton (Author) - University of Sydney
A A Moustafa (Author) - Western Sydney University
S J G Lewis (Author) - University of Sydney
Publication details: Journal of Neurology, Vol.265(6), pp.1353-1364
Publisher: Springer Medizin
Date published: 2018
DOI: 10.1007/s00415-018-8846-3
ISSN: 0340-5354
Organisation Unit: School of Science and Engineering - Legacy; School of Health - Nursing; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99450714502621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Clinical Neurology

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