Journal article
Alterations in theta activity associated with novelty and routinization processing in ADHD
Clinical Neurophysiology, Vol.121(8), pp.1336-1342
2010
Abstract
Objective: Novelty and routinization-related information processing disturbances were examined in adolescent males with ADHD using an oddball paradigm and electrophysiological measurement of theta (4-7. Hz) activity. Methods: Fifty-four unmedicated adolescent males (12-18. years) with Attention Deficit Hyperactivity Disorder (ADHD) and matched controls performed an auditory oddball task. Theta activity was sub-averaged, and Fourier Integrals with simultaneous measurement of electrodermal activity (EDA) was used to index response to stimulus novelty and routinization. Results: ADHD participants showed an overall increase in theta activity to both novel and routine stimuli relative to controls. While controls showed increased theta activity in response to novel compared to routine targets across the brain, ADHD participants did not show this novelty-related increase in theta activity in the right anterior/frontal brain. Conclusions: The findings of this study are consistent with disturbances in theta activity and the brain substrates of novelty relative to routinization-related processing in ADHD. Significance: These findings show that there are distinct alterations in theta activity related to stimulus novelty and routinization during an auditory oddball task in ADHD, and they highlight the value of using an event-related approach to elucidate the neural substrates of stimulus processing in ADHD. © 2010 International Federation of Clinical Neurophysiology.
Details
- Title
- Alterations in theta activity associated with novelty and routinization processing in ADHD
- Authors
- K Fallahpour (Author) - The Brain Resource Center, United StatesS D Clarke (Author) - Centre for Research into Adolescents' Health (CRASH)E Goldberg (Author) - New York University School of Medicine, United StatesDaniel F Hermens (Author) - Brain and Mind Research InstituteE M Falconer (Author) - The Brain Resource Center, United StatesE Gordon (Author) - Ultimo Brain Resource
- Publication details
- Clinical Neurophysiology, Vol.121(8), pp.1336-1342
- Publisher
- Elsevier Ireland Ltd.
- DOI
- 10.1016/j.clinph.2010.02.152
- ISSN
- 1388-2457
- Organisation Unit
- Thompson Institute; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99450515402621
- Output Type
- Journal article
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- Clinical Neurology
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