Alterations in theta activity associated with novelty and routinization processing in ADHD

K Fallahpour; S D Clarke; E Goldberg; Daniel F Hermens; E M Falconer; E Gordon

doi:10.1016/j.clinph.2010.02.152

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Alterations in theta activity associated with novelty and routinization processing in ADHD

Journal article

Peer reviewed

Alterations in theta activity associated with novelty and routinization processing in ADHD

K Fallahpour, S D Clarke, E Goldberg, Daniel F Hermens, E M Falconer and E Gordon

Clinical Neurophysiology, Vol.121(8), pp.1336-1342

2010

DOI: https://doi.org/10.1016/j.clinph.2010.02.152

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Abstract

ADHD

theta

EEG

attention

novelty

routinization

salience

Objective: Novelty and routinization-related information processing disturbances were examined in adolescent males with ADHD using an oddball paradigm and electrophysiological measurement of theta (4-7. Hz) activity. Methods: Fifty-four unmedicated adolescent males (12-18. years) with Attention Deficit Hyperactivity Disorder (ADHD) and matched controls performed an auditory oddball task. Theta activity was sub-averaged, and Fourier Integrals with simultaneous measurement of electrodermal activity (EDA) was used to index response to stimulus novelty and routinization. Results: ADHD participants showed an overall increase in theta activity to both novel and routine stimuli relative to controls. While controls showed increased theta activity in response to novel compared to routine targets across the brain, ADHD participants did not show this novelty-related increase in theta activity in the right anterior/frontal brain. Conclusions: The findings of this study are consistent with disturbances in theta activity and the brain substrates of novelty relative to routinization-related processing in ADHD. Significance: These findings show that there are distinct alterations in theta activity related to stimulus novelty and routinization during an auditory oddball task in ADHD, and they highlight the value of using an event-related approach to elucidate the neural substrates of stimulus processing in ADHD. © 2010 International Federation of Clinical Neurophysiology.

Details

Title: Alterations in theta activity associated with novelty and routinization processing in ADHD
Authors: K Fallahpour (Author) - The Brain Resource Center, United States
S D Clarke (Author) - Centre for Research into Adolescents' Health (CRASH)
E Goldberg (Author) - New York University School of Medicine, United States
Daniel F Hermens (Author) - Brain and Mind Research Institute
E M Falconer (Author) - The Brain Resource Center, United States
E Gordon (Author) - Ultimo Brain Resource
Publication details: Clinical Neurophysiology, Vol.121(8), pp.1336-1342
Publisher: Elsevier Ireland Ltd.
Date published: 2010
DOI: 10.1016/j.clinph.2010.02.152
ISSN: 1388-2457
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450515402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences

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