Journal article
Alterations in hypothalamic NPY and CRF in anorexic tumor-bearing rats
American Journal of Physiology: Endocrinology and Metabolism, Vol.264(4), pp.E638-E643
1993
PMID: 8476042
Abstract
Regional hypothalamic concentrations of neuropeptide Y (NPY) and corticotropin-releasing factor (CRF), respectively a stimulant and an inhibitor of feeding behavior, were investigated in hypothalamic nuclei in rats carrying the Yoshida sarcoma. Tumor-bearing rats (n = 10), non-tumor-bearing controls (n = 10), and food-restricted rats (n = 10), which did not carry tumors but were pair-fed to match the reduced food intake of the tumor-bearing group, were studied after 10 days. NPY concentrations in the arcuate nucleus (ARC, the main site of NPY synthesis) were significantly increased above controls (P < 0.01) in both tumor-bearing and food-restricted groups. However, NPY concentrations in the paraventricular nucleus (PVN, an NPY-sensitive site of NPY release) showed opposing changes, with a 25% decrease (P = 0.052) in the tumor-bearing but a 48% increase (P < 0.01) in the food-restricted group. CRF concentrations in both the PVN and the ARC were significantly reduced (P < 0.01) in the food-restricted group, but remained close to control values in the tumor-bearing group (P not significant). Changes in hypothalamic appetite-regulating neuropeptides in cancer anorexia, which may result from the action of cytokines produced by a host defense response or the tumor itself, may account for reduced feeding. Such changes may include impaired activity of NPY or failure of CRF activity to be suppressed after underfeeding and weight loss.
Details
- Title
- Alterations in hypothalamic NPY and CRF in anorexic tumor-bearing rats
- Authors
- H. D. McCarthy (Author) - University of LiverpoolP. E. McKibbin (Author) - University of LiverpoolA. V. Perkins (Author) - University of LiverpoolE. A. Linton (Author) - University of LiverpoolG. Williams (Author) - University of Liverpool
- Publication details
- American Journal of Physiology: Endocrinology and Metabolism, Vol.264(4), pp.E638-E643
- Publisher
- American Physiological Society
- DOI
- 10.1152/ajpendo.1993.264.4.E638
- ISSN
- 1522-1555
- PMID
- 8476042
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health
- Language
- English
- Record Identifier
- 99685294102621
- Output Type
- Journal article
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