Alloimmune neonatal neutropenia linked to anti-HNA-4a

Yoke Lin Fung; L A Pitcher; J E Willett; C Reed; L Mison; J Bux; G Eiber; R M Minchinton

doi:10.1046/j.1365-3148.2003.00413.x

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Alloimmune neonatal neutropenia linked to anti-HNA-4a

Journal article

Peer reviewed

Alloimmune neonatal neutropenia linked to anti-HNA-4a

Yoke Lin Fung, L A Pitcher, J E Willett, C Reed, L Mison, J Bux, G Eiber and R M Minchinton

Transfusion Medicine, Vol.13(1), pp.49-52

2003

DOI: https://doi.org/10.1046/j.1365-3148.2003.00413.x

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Abstract

Clinical Sciences

This is a novel case report of alloimmune neonatal neutropenia (ANN) linked to the neutrophil antibody anti-HNA-4a (MART). Since its discovery, the HNA-4a antigen has never been associated with any clinical neutropenia. A first-born neonate with respiratory distress was found to be severely neutropenic, because of ANN. The broad reactivity of the antibody together with its capture by CD11b and CD18 in monoclonal antibody immobilization of granulocyte antigen test suggested HNA-4a specificity. DNA sequencing confirmed that the father is HNA-4a-positive and that the mother is HNA-4a-negative, supporting the diagnosis of ANN linked to MART.

Details

Title: Alloimmune neonatal neutropenia linked to anti-HNA-4a
Authors: Yoke Lin Fung (Author) - Australian Red Cross Blood Service
L A Pitcher (Author) - Australian Red Cross Blood Service
J E Willett (Author) - Australian Red Cross Blood Service
C Reed (Author) - Australian Red Cross Blood Service
L Mison (Author) - Australian Red Cross Blood Service
J Bux (Author) - Australian Red Cross Blood Service
G Eiber (Author) - Australian Red Cross Blood Service
R M Minchinton (Author) - Australian Red Cross Blood Service
Publication details: Transfusion Medicine, Vol.13(1), pp.49-52
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2003
DOI: 10.1046/j.1365-3148.2003.00413.x
ISSN: 0958-7578
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450094002621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Hematology

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