Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult

K M Chitty; Jim Lagopoulos; I B Hickie; Daniel F Hermens

doi:10.1016/j.neubiorev.2015.07.004

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Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult

Journal article

Open access

Peer reviewed

Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult

K M Chitty, Jim Lagopoulos, I B Hickie and Daniel F Hermens

Neuroscience and Biobehavioral Reviews, Vol.56, pp.193-206

2015

DOI: https://doi.org/10.1016/j.neubiorev.2015.07.004

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Abstract

bipolar disorder

mismatch negativity

magnetic resonance spectroscopy

NMDA receptor

glutathione

In a series of neurophysiological and neuroimaging studies we investigated the neurobiology related to alcohol use in young people with bipolar disorder. Impairments were identified across frontal and temporal representations of event-related potential and proton magnetic resonance spectroscopy markers; mismatch negativity and in vivo glutathione, respectively. We propose these findings reflect impairments in the N-methyl-d-aspartate receptor and antioxidant capacity. This review seeks to place these findings within the broader literature in the context of two propositions: 1. Pathophysiological impairments in N-methyl-d-aspartate receptor functioning in bipolar disorder contribute to susceptibility toward developing alcohol problems. 2. Alcohol aggravates bipolar disorder neuroprogression via oxidative stress.A neurobiological model that incorporates these propositions is presented, with a focus on the potential for N-methyl-. d-aspartate receptor antagonism and glutathione augmentation as potential adjunctive pharmacotherapies to treat the comorbidity. While this review highlights the importance of alcohol monitoring and reduction strategies in the treatment of bipolar disorder, the clinical impact of the proposed model remains limited by the lack of controlled trials of novel pharmacological interventions. © 2015 Elsevier Ltd.

Details

Title: Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult
Authors: K M Chitty (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
Publication details: Neuroscience and Biobehavioral Reviews, Vol.56, pp.193-206
Publisher: Pergamon
Date published: 2015
DOI: 10.1016/j.neubiorev.2015.07.004
ISSN: 0149-7634
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99448910602621
Output Type: Journal article

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