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Alcohol misuse in emerging adulthood - Association of dopamine and serotonin receptor genes with impulsivity-related cognition668.25 kB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Alcohol misuse in emerging adulthood: Association of dopamine and serotonin receptor genes with impulsivity-related cognition
Addictive Behaviors, Vol.63, pp.29-36
2016
PMID: 27399274
Abstract
Impulsivity predicts alcohol misuse and risk for alcohol use disorder. Cognition mediates much of this association. Genes also account for a large amount of variance in alcohol misuse, with dopamine and serotonin receptor genes of particular interest, because of their role in motivated behavior. The precise psychological mechanisms through which such genes confer risk is unclear. Trait impulsivity conveys risk for alcohol misuse by influencing two distinct domains of cognition: beliefs about the reinforcing effects of alcohol consumption (positive alcohol expectancy) and the perceived ability to resist it (drinking refusal self-efficacy). This study investigated the effect of the dopamine-related polymorphism in the DRD2/ANKK1 gene (rs1800497) and a serotonin-related polymorphism in the HTR2A gene (rs6313) on associations between impulsivity, cognition, and alcohol misuse in 120 emerging adults (18–21 years). HTR2A predicted lower positive alcohol expectancy, higher refusal self-efficacy, and lower alcohol misuse. However, neither polymorphism moderated the linkages between impulsivity, cognition, and alcohol misuse. This is the first report of an association between HTR2A and alcohol-related cognition. Theoretically-driven biopsychosocial models have potential to elucidate the specific cognitive mechanisms through which distal risk factors like genes and temperament affect alcohol misuse in emerging adulthood.
Details
- Title
- Alcohol misuse in emerging adulthood: Association of dopamine and serotonin receptor genes with impulsivity-related cognition
- Authors
- Talia E Leamy (Author) - The University of QueenslandJason P Connor (Author) - The University of QueenslandJoanne Voisey (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of TechnologyMatthew J Gullo (Author) - Queensland University of Technology
- Publication details
- Addictive Behaviors, Vol.63, pp.29-36
- Publisher
- Elsevier Ltd
- Date published
- 2016
- DOI
- 10.1016/j.addbeh.2016.05.008
- ISSN
- 1873-6327; 0306-4603
- PMID
- 27399274
- Copyright note
- Copyright © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551007002621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Psychology, Clinical
- Substance Abuse
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