Journal article
Agonist-evoked endothelial Ca2+ signalling microdomains
Current Opinion in Pharmacology, Vol.45, pp.8-15
2019
Abstract
Localized, oscillating Ca2+ signals have been identified in discrete microdomains of vascular endothelial cells. At myoendothelial contacts (between endothelial and smooth muscle cells), both endothelial Ca2+ pulsars (IP3-mediated release of intracellular Ca2+) and Ca2+ sparklets (extracellular Ca2+ entry via TRP channels) contribute to endothelium-dependent hyperpolarization of smooth muscle, vasodilation, and feedback control of vasoconstriction. Ca2+ sparklets occurring at close-contact domains between endothelial cells are possibly involved in conducted hyperpolarization and spreading vasodilation in arterial networks. This review summarizes these Ca2+ signalling phenomena, examines the proposed mechanisms leading to their generation by G-protein-coupled receptor agonists, and explores the proposed physiological roles of these localized and specialized Ca2+ signals.
Details
- Title
- Agonist-evoked endothelial Ca2+ signalling microdomains
- Authors
- Timothy V Murphy (Author) - University of New South WalesShaun L Sandow (Author) - University of the Sunshine Coast - School of Health & Sports Sciences
- Publication details
- Current Opinion in Pharmacology, Vol.45, pp.8-15
- Publisher
- Elsevier Ltd.
- Date published
- 2019
- DOI
- 10.1016/j.coph.2019.03.005
- ISSN
- 1471-4892
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450676402621
- Output Type
- Journal article
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- Pharmacology & Pharmacy
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