Journal article
Ageing of the retinal pigment epithelium: Implications for transplantation
Graefe's Archive for Clinical and Experimental Ophthalmology, Vol.242(1), pp.76-84
2004
Abstract
This review will discuss some of the implications for using cells from aged donors for retinal pigment epithelium (RPE) transplantation. It will consider age-related changes in the structure and function of RPE cells and the accumulation of potentially damaging photoreactive constituents. The review will focus on the role of the ocular pigments lipofuscin and melanin in respect to age-related changes in composition, photoreactivity and potential role in retinal ageing and age-related macular degeneration. The article concludes by considering the suitability of senescent RPE cells for transplantation and whether such cells can be rejuvenated.
Details
- Title
- Ageing of the retinal pigment epithelium: Implications for transplantation
- Authors
- M Boulton (Author) - University of Cardiff, United KingdomM Rózanowska (Author) - University of Cardiff, United KingdomTim J Wess (Author) - University of Cardiff, United Kingdom
- Publication details
- Graefe's Archive for Clinical and Experimental Ophthalmology, Vol.242(1), pp.76-84
- Publisher
- Springer
- Date published
- 2004
- DOI
- 10.1007/s00417-003-0812-8
- ISSN
- 0721-832X
- Organisation Unit
- Office of the Deputy Vice-Chancellor (Academic); University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99450663002621
- Output Type
- Journal article
Metrics
149 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Web Of Science research areas
- Ophthalmology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites