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Ageing does not impair motor neuron adaptations: comparable motor unit responses to strength training in young and older adults
Journal article   Open access   Peer reviewed

Ageing does not impair motor neuron adaptations: comparable motor unit responses to strength training in young and older adults

Andrea Casolo, Stefanie Del Vecchio, Benjamin I Goodlich, Bastian Schrader, Stefano Nuccio, Edoardo Lecce, Ilenia Bazzucchi, Luca Angius, Francesco Felici, Joachim Schrader, …
The Journal of Physiology, Vol.604(7), pp.2796-2815
2026
DOI: https://doi.org/10.1113/JP290541
PMID: 41823343
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The Journal of Physiology - 2026 - Casolo - Ageing does not impair motor neuron adaptations comparable motor unit2.35 MBDownloadView
Published VersionCC BY V4.0,  Open Access

Abstract

motor unit strength training high‐density surface EMG ageing motor neuron
Ageing induces structural and functional changes in the neuromuscular systems that impair voluntary force production, compromising daily function and wellbeing. We examined whether older adults preserve the capacity for motor unit adaptations to a short-term strength training intervention previously shown to enhance neural drive to muscle in young adults. Twenty‑three older adults were assigned to a training group (INT, n = 13, 71 ± 4 years of age) or a control group (CON, n = 10, 69 ± 2 years of age) and completed pre- and postintervention assessments of ankle dorsiflexor maximal voluntary force (MVF). Motor unit behaviour was analysed from high‑density surface EMG recorded from tibialis anterior during submaximal trapezoidal contractions. The INT group performed a 4 week supervised isometric strength training programme, whereas the CON group maintained habitual activity. High‑density surface EMG signals were decomposed into individual motor units, tracked longitudinally across sessions. Training increased MVF by 17.6% and enhanced motor unit discharge rate at recruitment (+8.2%, P = 0.031) and constant force (+11.3%, P < 0.001), without changes in recruitment or derecruitment thresholds. Estimates of persistent inward currents (delta frequency) increased (+1.0 pulses per second) and were positively correlated with changes in discharge rate, which, in turn, were correlated with gains in MVF (rrm = 0.54–0.57, P < 0.05). This pattern suggests that enhanced intrinsic excitability and synaptic input to motor neurons contributed to improvements in strength. These results demonstrate that, despite age-related motor unit remodelling, the ageing nervous system remains responsive to targeted strength training, preserving the capacity for meaningful neural adaptations.

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