Journal article
Advances in molecular genetics and the prevention and treatment of substance misuse: Implications of association studies of the A 1 allele of the D 2 dopamine receptor gene
Addictive Behaviors, Vol.29(7), pp.1275-1294
2004
Abstract
Substance misuse is influenced by multiple genetic and environmental factors. Recent research has identified a number of potential genetic markers of risk and those associated with drug reward substrates show particular promise. The current study reexamines the extant published data of the association between the D2 dopamine receptor (DRD2) gene minor Taq 1A (A1) allele and substance misuse risk. A series of meta-analyses was performed on 64 studies examining DRD2 A1+ allelic status and substance misuse. In addition, personality was examined as a possible endophenotype. Significant association was found between the A1 allele and severe substance dependence in both Caucasian and non-Caucasian groups. The data did not support a significant association between the A1 allele and personality features. While the specific mechanism underlying these associations requires further elucidation, this genetic marker shows promise as a marker of brain reinforcement processes. Possible ways of utilising the A1 allele to inform prevention and treatment initiatives are discussed.
Details
- Title
- Advances in molecular genetics and the prevention and treatment of substance misuse: Implications of association studies of the A 1 allele of the D 2 dopamine receptor gene
- Authors
- Ross Young (Author) - Queensland University of TechnologyBruce R Lawford (Author) - Royal Brisbane and Women's HospitalA Nutting (Author) - Queensland University of TechnologyErnest P Noble (Author) - UCLA Neuropsychiatric Institute
- Publication details
- Addictive Behaviors, Vol.29(7), pp.1275-1294
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.addbeh.2004.06.012
- ISSN
- 1873-6327
- Organisation Unit
- Office of the Deputy Vice-Chancellor (Research and Innovation); University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99551007402621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Psychology, Clinical
- Substance Abuse
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Source: InCites