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Published VersionCC BY V4.0, Open Access
Journal article
Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
Scientific Reports, Vol.11, pp.1-10
2021
Abstract
To examine if skin autofluorescence (sAF) differed in early adulthood between individuals with type 1 diabetes and age-matched controls and to ascertain if sAF aligned with risk for kidney disease. Young adults with type 1 diabetes (N = 100; 20.0 ± 2.8 years; M:F 54:46; FBG-11.6 ± 4.9 mmol/mol; diabetes duration 10.7 ± 5.2 years; BMI 24.5(5.3) kg/m2) and healthy controls (N = 299; 20.3 ± 1.8 years; M:F-83:116; FBG 5.2 ± 0.8 mmol/L; BMI 22.5(3.3) kg/m2) were recruited. Skin autofluorescence (sAF) and circulating AGEs were measured. In a subset of both groups, kidney function was estimated by GFR CKD-EPI CysC and uACR, and DKD risk defined by uACR tertiles. Youth with type 1 diabetes had higher sAF and BMI, and were taller than controls. For sAF, 13.6% of variance was explained by diabetes duration, height and BMI (P model = 1.5 × 10–12). In the sub-set examining kidney function, eGFR and sAF were higher in type 1 diabetes versus controls. eGFR and sAF predicted 24.5% of variance in DKD risk (P model = 2.2 × 10–9), which increased with diabetes duration (51%; P model < 2.2 × 10–16) and random blood glucose concentrations (56%; P model < 2.2 × 10–16). HbA1C and circulating fructosamine albumin were higher in individuals with type 1 diabetes at high versus low DKD risk. eGFR was independently associated with DKD risk in all models. Higher eGFR and longer diabetes duration are associated with DKD risk in youth with type 1 diabetes. sAF, circulating AGEs, and urinary AGEs were not independent predictors of DKD risk. Changes in eGFR should be monitored early, in addition to uACR, for determining DKD risk in type 1 diabetes.
Details
- Title
- Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
- Authors
- Josephine M Forbes (Corresponding Author) - The University of QueenslandSelena Le Bagge (Author) - The University of QueenslandSamuel Righi (Author) - The University of QueenslandAmelia K Fotheringham (Author) - The University of QueenslandLinda A Gallo (Author) - The University of QueenslandDomenica A McCarthy (Author) - 37 Kent Street, Brisbane, QLD 4102 AustraliaSherman Leung (Author) - The University of QueenslandTracey Baskerville (Author) - The University of QueenslandJanelle Nisbett (Author) - Mater Health ServicesAdam Morton (Author) - Mater Health ServicesStephanie Teasdale (Author) - Mater Health ServicesNeisha D’Silva (Author) - Mater Health ServicesHelen Barrett (Author) - Mater Health ServicesTimothy Jones (Author) - The Kids Research Institute AustraliaJennifer Couper (Author) - Women's and Children's HospitalKim Donaghue (Author) - Children's Hospital at WestmeadNicole Isbel (Author) - Princess Alexandra HospitalDavid W Johnson (Author) - St Lucia, QLD Australia The Metro South and Ipswich Nephrology and Transplant Service (MINTS), Brisbane, QLD AustraliaLeigh Donnellan (Author) - University of South AustraliaPermal Deo (Author) - University of South AustraliaLisa K Akison (Author) - The University of QueenslandKaren M Moritz (Author) - The University of QueenslandTrisha O’Moore-Sullivan (Author) - Mater Health Services
- Publication details
- Scientific Reports, Vol.11, pp.1-10
- Publisher
- Nature Publishing Group
- Date published
- 2021
- DOI
- 10.1038/s41598-021-88786-4
- ISSN
- 2045-2322
- Copyright note
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99620308302621
- Output Type
- Journal article
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