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Advanced Glycation End Products (AGEs) and Chronic Kidney Disease_ Does the Modern Diet AGE the Kidney1.80 MB
Published VersionCC BY V4.0, Open Access
Published VersionCC BY V4.0, Open
Journal article
Advanced Glycation End Products (AGEs) and Chronic Kidney Disease: Does the Modern Diet AGE the Kidney?
Nutrients, Vol.14(13), pp.1-28
2022
Abstract
Since the 1980s, chronic kidney disease (CKD) affecting all ages has increased by almost 25%. This increase may be partially attributable to lifestyle changes and increased global consumption of a “western” diet, which is typically energy dense, low in fruits and vegetables, and high in animal protein and ultra-processed foods. These modern food trends have led to an increase in the consumption of advanced glycation end products (AGEs) in conjunction with increased metabolic dysfunction, obesity and diabetes, which facilitates production of endogenous AGEs within the body. When in excess, AGEs can be pathological via both receptor-mediated and non-receptor-mediated pathways. The kidney, as a major site for AGE clearance, is particularly vulnerable to AGE-mediated damage and increases in circulating AGEs align with risk of CKD and all-cause mortality. Furthermore, individuals with significant loss of renal function show increased AGE burden, particularly with uraemia, and there is some evidence that AGE lowering via diet or pharmacological inhibition may be beneficial for CKD. This review discusses the pathways that drive AGE formation and regulation within the body. This includes AGE receptor interactions and pathways of AGE-mediated pathology with a focus on the contribution of diet on endogenous AGE production and dietary AGE consumption to these processes. We then analyse the contribution of AGEs to kidney disease, the evidence for dietary AGEs and endogenously produced AGEs in driving pathogenesis in diabetic and non-diabetic kidney disease and the potential for AGE targeted therapies in kidney disease.
Details
- Title
- Advanced Glycation End Products (AGEs) and Chronic Kidney Disease: Does the Modern Diet AGE the Kidney?
- Authors
- Amelia K. Fotheringham (Author) - The University of QueenslandLinda Gallo (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyDanielle Borg (Author) - The University of QueenslandJosephine M Forbes (Author) - The University of Queensland
- Publication details
- Nutrients, Vol.14(13), pp.1-28
- Publisher
- MDPI AG
- Date published
- 2022
- DOI
- 10.3390/nu14132675
- ISSN
- 2072-6643
- Copyright note
- Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- School of Health - Biomedicine; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99652298302621
- Output Type
- Journal article
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