Additively Manufactured Iron-Manganese for Biodegradable Porous Load-Bearing Bone Scaffold Applications

Danilo Carluccio; Chun Xu; Jeffrey Venezuela; Yuxue Cao; Damon Kent; Michael Bermingham; Ali Gokhan Demir; Barbara Previtali; Ye Qingsong; Matthew Dargusch

doi:10.1016/j.actbio.2019.12.018

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Additively Manufactured Iron-Manganese for Biodegradable Porous Load-Bearing Bone Scaffold Applications

Journal article

Peer reviewed

Additively Manufactured Iron-Manganese for Biodegradable Porous Load-Bearing Bone Scaffold Applications

Danilo Carluccio, Chun Xu, Jeffrey Venezuela, Yuxue Cao, Damon Kent, Michael Bermingham, Ali Gokhan Demir, Barbara Previtali, Ye Qingsong and Matthew Dargusch

Acta Biomaterialia, Vol.103, pp.346-360

2020

DOI: https://doi.org/10.1016/j.actbio.2019.12.018

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Abstract

Selective Laser Melting

Biodegradable Iron

Bone Scaffolds

in vivo testing

biological characterisation

corrosion testing

mechanical characterisation

Selective laser melting (SLM) can produce complex hierarchical architectures paving the way for highly customisable biodegradable load-bearing bone scaffolds. For the first time, an in-depth analysis on the performance of SLM-manufactured iron-manganese bone scaffolds suitable for load-bearing applications is presented. Microstructural, mechanical, corrosion and biological characterisations were performed on SLM-manufactured iron-manganese scaffolds. The microstructure of the scaffold consisted primarily of γ-austenite, leading to high ductility. The mechanical properties of the scaffold were sufficient for load-bearing applications even after 28 days immersion in simulated body fluids. Corrosion tests showed that the corrosion rate was much higher than bulk pure iron, attributed to a combination of the manufacturing method, the addition of Mn to the alloy and the design of the scaffold. In vitro cell testing showed that the scaffold had good biocompatibility and viability towards mammalian cells. Furthermore, the presence of filopodia showed good osteoblast adhesion. In vivo analysis showed successful bone integration with the scaffold, with new bone formation observed after 4 weeks of implantation. Overall the SLM manufactured porous Fe-35Mn implant showed promise for biodegradable load-bearing bone scaffold applications.

Details

Title: Additively Manufactured Iron-Manganese for Biodegradable Porous Load-Bearing Bone Scaffold Applications
Authors: Danilo Carluccio (Author) - University of Queensland
Chun Xu (Author) - University of Queensland
Jeffrey Venezuela (Author) - University of Queensland
Yuxue Cao (Author) - University of Queensland
Damon Kent (Author) - University of the Sunshine Coast - School of Science & Engineering
Michael Bermingham (Author) - University of Queensland
Ali Gokhan Demir (Author) - Politecnico di Milano, Italy
Barbara Previtali (Author) - Politecnico di Milano, Italy
Ye Qingsong (Author) - University of Queensland
Matthew Dargusch (Author) - University of Queensland
Publication details: Acta Biomaterialia, Vol.103, pp.346-360
Publisher: Elsevier BV
Date published: 2020
DOI: 10.1016/j.actbio.2019.12.018
ISSN: 1742-7061
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
Language: English
Record Identifier: 99451414102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Engineering, Biomedical; Materials Science, Biomaterials