Journal article
Acute high intensity interval exercise reduces colon cancer cell growth
The Journal of Physiology, Vol.597(8), pp.2177-2184
2019
PMCID: PMC6462486
PMID: 30812059
Abstract
Physical activity is associated with significant reductions in colorectal cancer mortality. However, the mechanisms by which exercise mediates this anti‐oncogenic effect are not clear. In the present study, colorectal cancer survivors completed acute (n = 10) or chronic (n = 10) exercise regimes. An acute high intensity interval exercise session (HIIE; 4 × 4 min at 85–95% peak heart rate) was completed with serum samples collected at baseline, as well as 0 and 120 min post‐exercise. For the ‘chronic’ intervention, resting serum was sampled before and after 4 weeks (12 sessions) of HIIE. The effect of serum on colon cancer cell growth was evaluated by incubating cells (CaCo‐2 and LoVo) for up to 72 h and assessing cell number. Serum obtained immediately following HIIE, but not 120 min post‐HIIE, significantly reduced colon cancer cell number. Significant increases in serum interleukin‐6 (P = 0.023), interleukin‐8 (P = 0.036) and tumour necrosis factor‐α (P = 0.003) were found immediately following acute HIIE. At rest, short‐term HIIE training did not promote any changes in cellular growth or cytokine concentrations. The acute effects of HIIE and the cytokine flux may be important mediators of reducing colon cancer cell progression. Repetitive exposure to these acute effects may contribute to the relationship between exercise and improved colorectal cancer survival.
Details
- Title
- Acute high intensity interval exercise reduces colon cancer cell growth
- Authors
- James L Devin (Corresponding Author) - University of QueenslandMichelle M Hill (Author) - University of QueenslandMarina Mourtzakis (Author) - University of WaterlooJoe Quadrilatero (Author) - University of WaterlooDavid G Jenkins (Author) - University of QueenslandTina L Skinner (Author) - University of Queensland
- Publication details
- The Journal of Physiology, Vol.597(8), pp.2177-2184
- Publisher
- Wiley-Blackwell Publishing Ltd.
- DOI
- 10.1113/JP277648
- ISSN
- 1469-7793
- PMID
- 30812059; PMC6462486
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99488703902621
- Output Type
- Journal article
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