Acute Inflammatory Responses to Exercise in Patients with Abdominal Aortic Aneurysm

Mark Windsor; Tom G Bailey; Maria-Christina Perissiou; Kim Greaves; Pankaj Jha; Anthony S Leicht; Fraser D Russell; Jonathan Golledge; Christopher D Askew

doi:10.1249/MSS.0000000000001501

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Acute Inflammatory Responses to Exercise in Patients with Abdominal Aortic Aneurysm

Journal article

Open access

Peer reviewed

Acute Inflammatory Responses to Exercise in Patients with Abdominal Aortic Aneurysm

Mark Windsor, Tom G Bailey, Maria-Christina Perissiou, Kim Greaves, Pankaj Jha, Anthony S Leicht, Fraser D Russell, Jonathan Golledge and Christopher D Askew

Medicine and Science in Sports and Exercise, Vol.50(4), pp.649-658

2018

DOI: https://doi.org/10.1249/MSS.0000000000001501

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Abstract

inflammation

matrix metalloproteinase

cytokines

tumour necrosis factor-α

cardiovascular disease

Purpose: Inflammation and extracellular matrix degeneration contribute to abdominal aortic aneurysm (AAA) development. We aimed to assess the effect of exercise intensity on circulating biomarkers of inflammation and extracellular matrix degeneration in patients with AAA and healthy older adults. Methods: Twenty patients with AAA (74±6y) and twenty healthy males (72±5y) completed moderate-intensity cycling at 40% peak power output (PPO), higher-intensity intervals at 70% PPO, and control (rest) on separate days. Circulating matrix metalloproteinase-9 (MMP-9), transforming growth factor beta 1 (TGF-β1), interleukin-6 (IL-6), IL-10 and tumour necrosis factor alpha (TNF-α) were analysed at rest, and 0 to 90 min post. Results: Biomarkers at baseline were similar between groups. IL-6 responses to exercise were similar between groups, with a greater increase in ΔIL-6 after moderate-intensity compared to higher-intensity exercise (P<0.001). Delta MMP-9 showed a 118 ng/ml (95% CI, 23 to 214, P=0.02) greater increase immediately after higher-intensity exercise compared to changes in control in both groups. Delta MMP-9 then decreased by 114 ng/ml (18 to 211, P=0.02) 90 min after higher-intensity exercise compared to the changes in control. Delta TNF-α was not different between protocols in healthy adults. In patients with AAA, delta TNF-α showed a greater decrease after higher-intensity compared to moderate-intensity exercise (-6.1 pg/ml, -8.5 to -3.6, P<0.001) and control (-4.9 pg/ml, -7.4 to -2.4, P<0.001). IL-10 and TGF-β1 did not change in either group. Conclusions: These findings suggest that a bout of higher-intensity exercise elicits a greater anti-inflammatory response compared to moderate-intensity exercise, which may be further augmented in patients with AAA. Exercise-induced reductions in biomarkers associated with AAA progression may represent a protective effect of exercise in patients with AAA.

Details

Title: Acute Inflammatory Responses to Exercise in Patients with Abdominal Aortic Aneurysm
Authors: Mark Windsor (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Tom G Bailey (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Maria-Christina Perissiou (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Kim Greaves (Author) - Sunshine Coast Health Services
Pankaj Jha (Author) - Sunshine Coast Health Services
Anthony S Leicht (Author) - James Cook University
Fraser D Russell (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Jonathan Golledge (Author) - James Cook University
Christopher D Askew (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Medicine and Science in Sports and Exercise, Vol.50(4), pp.649-658
Publisher: Lippincott Williams & Wilkins
Date published: 2018
DOI: 10.1249/MSS.0000000000001501
ISSN: 0195-9131
Copyright note: Copyright © 2018 The Authors. This is a non-final version of an article published in final form in Windsor, Mark; Bailey, Tom G; Perissiou, Maria; Greaves, Kim; Jha, Pankaj; Leicht, Anthony S; Russell, F D; Golledge, Jonathan; Askew, C D (2018) Acute Inflammatory Responses to Exercise in Patients with Abdominal Aortic Aneurysm. Medicine and Science in Sports and Exercise. 50:4 649-658
Organisation Unit: School of Health - Biomedicine; Faculty of Science, Health, Education and Engineering; UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450316502621
Output Type: Journal article

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