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Acute Effects of Caffeine and Taurine Co-Ingestion on Time to Exhaustion and Thermoregulatory Responses to Cycling in the Heat
Journal article   Open access   Peer reviewed

Acute Effects of Caffeine and Taurine Co-Ingestion on Time to Exhaustion and Thermoregulatory Responses to Cycling in the Heat

James Aggett, Joe Page, Jenny Peel, Kevin John, Guilherme Matta, Jamie Tallent, Shane Heffernan, Owen Jeffries and Mark Waldron
European Journal of Sport Science, Vol.25(10), pp.1-12
2025
PMCID: PMC12439788
PMID: 40956767
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European Journal of Sport Science - 2025 - Aggett - Acute Effects of Caffeine and Taurine Co‐Ingestion on Time to1.13 MBDownloadView
Published Version Open Access CC BY V4.0

Abstract

endurance environmental physiology exercise nutrition performance
Caffeine and taurine are commonly co-ingested pre-exercise but elicit different thermoregulatory responses; however, their combined effect on thermoregulation is unknown. Therefore, we evaluated the effects of oral caffeine and taurine co-ingestion on time to exhaustion (TTE) and thermoregulatory responses to cycling in the heat at the gas exchange threshold (GET). Ten healthy nonheat acclimated participants took part in a double-blind crossover study, completing a TTE in the heat (35°C; 40% relative humidity), cycling at a power output associated with the GET and 1 h after ingesting: caffeine (5 mg/kg) and taurine (50 mg/kg) combined or placebo. Pulmonary gas exchange, core and mean skin temperatures and whole-body sweat rate (WBSR) were recorded throughout. Heat production was determined using partitional calorimetry. There were no differences in TTE between conditions (p = 0.608); however, the rate of oxygen consumption (p = 0.017), minute ventilation (p = 0.029) and heat production (p = 0.019) were higher following the supplement. There were no differences between conditions for skin (p = 0.539) and core temperature (p = 0.699), mean skin blood flow (p = 0.119), respiratory exchange ratio (p = 0.546) and WBSR (p = 0.897). Pre-exercise co-ingestion of caffeine and taurine in the heat had no ergogenic effect despite increasing the ventilatory and metabolic demand. Collectively, these data indicate minimal effects on whole-body thermoregulation.

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