Acute Dietary Nitrate Supplementation Improves Flow Mediated Dilatation of the Superficial Femoral Artery in Healthy Older Males

Meegan A Walker; Tom G Bailey; Luke McIlvenna; Jason D Allen; Daniel J Green; Christopher D Askew

doi:10.3390/nu11050954

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Acute Dietary Nitrate Supplementation Improves Flow Mediated Dilatation of the Superficial Femoral Artery in Healthy Older Males

Journal article

Open access

Peer reviewed

Acute Dietary Nitrate Supplementation Improves Flow Mediated Dilatation of the Superficial Femoral Artery in Healthy Older Males

Meegan A Walker, Tom G Bailey, Luke McIlvenna, Jason D Allen, Daniel J Green and Christopher D Askew

Nutrients, Vol.11(5), 954

2019

DOI: https://doi.org/10.3390/nu11050954

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Abstract

inorganic nitrate

beetroot juice

nitric oxide

endothelial function

arterial stiffness

blood flow

cardiovascular risk

Aging is often associated with reduced leg blood flow, increased arterial stiffness, and endothelial dysfunction, all of which are related to declining nitric oxide (NO) bioavailability. Flow mediated dilatation (FMD) and passive leg movement (PLM) hyperaemia are two techniques used to measure NO-dependent vascular function. We hypothesised that acute dietary nitrate (NO3-) supplementation would improve NO bioavailability, leg FMD, and PLM hyperaemia. Fifteen healthy older men (69±4 years) attended two experiment sessions and consumed either 140 mL of concentrated beetroot juice (800 mg NO3-) or placebo (NO3--depleted beetroot juice) in a randomised, double blind, cross-over design study. Plasma nitrite (NO2-) and NO3-, blood pressure (BP), augmentation index (AIx75), pulse wave velocity (PWV), FMD of the superficial femoral artery, and PLM hyperaemia were measured immediately before and 2.5 h after consuming NO3- and placebo. Placebo had no effect but NO3- led to an 8.6-fold increase in plasma NO2-, which was accompanied by an increase in FMD (NO3-: +1.18±0.94% vs. placebo: 0.23±1.13%, p = 0.002), and a reduction in AIx75 (NO3-: -8.7±11.6% vs. placebo: -4.6±5.5%, p = 0.027). PLM hyperaemia, BP, and PWV were unchanged during both trials. This study showed that a dose of dietary NO3- improved NO bioavailability and enhanced endothelial function as measured by femoral artery FMD. These findings provide insight into the specific central and peripheral vascular responses to dietary NO3- supplementation in older adults

Details

Title: Acute Dietary Nitrate Supplementation Improves Flow Mediated Dilatation of the Superficial Femoral Artery in Healthy Older Males
Authors: Meegan A Walker (Author) - University of the Sunshine Coast - School of Health and Sports Sciences
Tom G Bailey (Author) - University of the Sunshine Coast - School of Health and Sports Sciences
Luke McIlvenna (Author) - Victoria University
Jason D Allen (Author) - Victoria University
Daniel J Green (Author) - University of Western Australia
Christopher D Askew (Author) - University of the Sunshine Coast - School of Health and Sports Sciences
Publication details: Nutrients, Vol.11(5), 954
Publisher: MDPI AG
Date published: 2019
DOI: 10.3390/nu11050954
ISSN: 2072-6643
Copyright note: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Organisation Unit: UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99451253302621
Output Type: Journal article

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