Journal article
Activins and inhibins in mammalian testis development: New models, new insights
Molecular and Cellular Endocrinology, Vol.359, pp.66-77
2012
Abstract
The discovery of activin and inhibins as modulators of the hypothalamic-pituitary-gonadal axis has set the foundation for understanding their central importance to many facets of development and disease. This review contains an overview of the processes and cell types that are central to testis development and spermatogenesis and then provides an update focussed on information gathered over the past five years to address new concepts about how these proteins function to control testis development in fetal and juvenile life. Current knowledge about the interactive nature of the transforming growth factor-β (TGFβ) superfamily signalling network is applied to recent findings about activins and inhibins in the testis. Information about the regulated synthesis of signalling components and signalling regulators in the testis is integrated with new concepts that demonstrate their functional significance. The importance of activin bioactivity levels or dosage in controlling balanced growth of spermatogonial cells and their niche at different stages of testis development is highlighted. © 2012 Elsevier Ireland Ltd.
Details
- Title
- Activins and inhibins in mammalian testis development: New models, new insights
- Authors
- B Barakat (Author) - Monash UniversityCatherine Itman (Author) - Monash UniversityS H Mendis (Author) - Monash UniversityK L Loveland (Author) - Monash University
- Publication details
- Molecular and Cellular Endocrinology, Vol.359, pp.66-77
- Publisher
- Elsevier Ireland Ltd.
- Date published
- 2012
- DOI
- 10.1016/j.mce.2012.02.018
- ISSN
- 0303-7207
- Organisation Unit
- University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99449371002621
- Output Type
- Journal article
Metrics
563 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Web Of Science research areas
- Cell Biology
- Endocrinology & Metabolism
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites