Achyrodimer F, a tyrosyl-DNA phosphodiesterase I inhibitor from an Australian fungus of the family Cortinariaceae

L W Tian; Y Feng; Trong D Tran; Yoko Shimizu; T Pfeifer; H T Vu; R J Quinn

doi:10.1016/j.bmcl.2017.07.062

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Achyrodimer F, a tyrosyl-DNA phosphodiesterase I inhibitor from an Australian fungus of the family Cortinariaceae

Journal article

Peer reviewed

Achyrodimer F, a tyrosyl-DNA phosphodiesterase I inhibitor from an Australian fungus of the family Cortinariaceae

L W Tian, Y Feng, Trong D Tran, Yoko Shimizu, T Pfeifer, H T Vu and R J Quinn

Bioorganic & Medicinal Chemistry Letters, Vol.27(17), pp.4007-4010

2017

DOI: https://doi.org/10.1016/j.bmcl.2017.07.062

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Abstract

achyrodimer F

cyclobutane derivative

Tdp1

Fungus Cortinariaceae

DFT calculations

Mass-guided isolation of the dichloromethane/methanol extracts from a specimen of teleomorphic fungus of the family Cortinariaceae resulted in the identification of a new dimeric cyclobutane metabolite, achyrodimer F (1), along with the monomers hispidin (2) and bisnoryangonin (3). Their structures were determined by NMR and MS data analyses. Density Function Theory (DFT) NMR calculations was employed to confirm the chemical structure of achyrodimer F. Compound 1 inhibited tyrosyl-DNA phosphodiesterase I with an IC50 value of 1 μM. © 2017

Details

Title: Achyrodimer F, a tyrosyl-DNA phosphodiesterase I inhibitor from an Australian fungus of the family Cortinariaceae
Authors: L W Tian (Author) - Griffith University
Y Feng (Author) - Griffith University
Trong D Tran (Author) - Griffith University
Yoko Shimizu (Author) - Centre for Drug Research and Development, Canada
T Pfeifer (Author) - Centre for Drug Research and Development, Canada
H T Vu (Author) - Griffith University
R J Quinn (Author) - Griffith University
Publication details: Bioorganic & Medicinal Chemistry Letters, Vol.27(17), pp.4007-4010
Publisher: Pergamon
Date published: 2017
DOI: 10.1016/j.bmcl.2017.07.062
ISSN: 0960-894X
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450321002621
Output Type: Journal article

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Collaboration types: International collaboration
Web Of Science research areas: Chemistry, Medicinal; Chemistry, Organic

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