Acaricidal Activity of Eugenol Based Compounds against Scabies Mites

C J Pasay; Kate E Mounsey; G Stevenson; R Davis; L Arlian; M S Morgan; D Vyszenski-Moher; K Andrews; J S McCarthy

doi:10.1371/journal.pone.0012079

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Acaricidal Activity of Eugenol Based Compounds against Scabies Mites

Journal article

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Acaricidal Activity of Eugenol Based Compounds against Scabies Mites

C J Pasay, Kate E Mounsey, G Stevenson, R Davis, L Arlian, M S Morgan, D Vyszenski-Moher, K Andrews and J S McCarthy

PLoS One, Vol.5(8), e12079

2010

DOI: https://doi.org/10.1371/journal.pone.0012079

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Abstract

scabies

eugenol

Backgound: Human scabies is a debilitating skin disease caused by the "itch mite" Sarcoptes scabiei. Ordinary scabies is commonly treated with topical creams such as permethrin, while crusted scabies is treated with topical creams in combination with oral ivermectin. Recent reports of acaricide tolerance in scabies endemic communities in Northern Australia have prompted efforts to better understand resistance mechanisms and to identify potential new acaricides. In this study, we screened three essential oils and four pure compounds based on eugenol for acaricidal properties. Methodology/Principal Findings: Contact bioassays were performed using live permethrin-sensitive S. scabiei var suis mites harvested from pigs and permethrin-resistant S. scabiei var canis mites harvested from rabbits. Results of bioassays showed that clove oil was highly toxic against scabies mites. Nutmeg oil had moderate toxicity and ylang ylang oil was the least toxic. Eugenol, a major component of clove oil and its analogues -acetyleugenol and isoeugenol, demonstrated levels of toxicity comparable to benzyl benzoate, the positive control acaricide, killing mites within an hour of contact. Conclusions: The acaricidal properties demonstrated by eugenol and its analogues show promise as leads for future development of alternative topical acaricides to treat scabies.

Details

Title: Acaricidal Activity of Eugenol Based Compounds against Scabies Mites
Authors: C J Pasay (Author) - University of Queensland
Kate E Mounsey (Author) - University of Queensland
G Stevenson (Author) - Griffith University
R Davis (Author) - Griffith University
L Arlian (Author) - Wright State University, United States
M S Morgan (Author) - Wright State University, United States
D Vyszenski-Moher (Author) - Wright State University, United States
K Andrews (Author) - University of Queensland
J S McCarthy (Author) - University of Queensland
Publication details: PLoS One, Vol.5(8), e12079; 9
Publisher: Public Library of Science
Date published: 2010
DOI: 10.1371/journal.pone.0012079
ISSN: 1932-6203
Copyright note: Copyright © 2010 Pasay et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This published version is reproduced in accordance with this policy.
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450246902621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Entomology

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