Journal article
Abdominal aortic aneurysm and omega-3 polyunsaturated fatty acids: Mechanisms, animal models, and potential treatment
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), Vol.118, pp.1-9
2017
Abstract
Abdominal aortic aneurysm (AAA) is an inflammatory disease associated with macrophage accumulation in the adventitia, oxidative stress, medial elastin degradation and aortic dilation. Progression of AAA is linked to increased risk of rupture, which carries a high mortality rate. Drug therapies trialled to date lack efficacy and although aneurysm repair is available for patients with large aneurysm, peri-surgical morbidity and mortality have been widely reported. Recent studies using rodent models of AAA suggest that long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) and their metabolites can moderate inflammation and oxidative stress perpetuated by infiltrating macrophages and intervene in the destruction of medial elastin. This review examines evidence from these animal studies and related reports of inhibition of inflammation and arrest of aneurysm development following prophylactic supplementation with LC n-3 PUFAs. The efficacy of LC n-3 PUFAs for management of existing aneurysm is unclear and further investigations involving human clinical trials are warranted.
Details
- Title
- Abdominal aortic aneurysm and omega-3 polyunsaturated fatty acids: Mechanisms, animal models, and potential treatment
- Authors
- Lara T Meital (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringShaun L Sandow (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringPhilip C Calder (Author) - University of Southampton, United KingdomFraser D Russell (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Publication details
- Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), Vol.118, pp.1-9
- Publisher
- Churchill Livingstone
- Date published
- 2017
- DOI
- 10.1016/j.plefa.2017.02.001
- ISSN
- 0952-3278
- Copyright note
- Copyright © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450695402621
- Output Type
- Journal article
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- Biochemistry & Molecular Biology
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- Endocrinology & Metabolism
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