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A volumetric study of molecular inclusion by α-cyclodextrin
Journal article   Peer reviewed

A volumetric study of molecular inclusion by α-cyclodextrin

N S Isaacs and David James Young
Tetrahedron Letters, Vol.40(20), pp.3953-3956
1999
url
https://doi.org/10.1016/S0040-4039(99)00619-XView
Published Version

Abstract

cyclodextrins inclusion
The reaction volume (Δ vÌ„ c→0) associated with inclusion of 3- nitrophenol by αcyclodextrin was determined by densitometry to be -9 cm3 mol-1 while the corresponding value for encapsulation of methyl orange by two molecules of α-cyclodextrin is +27 cm3 mol-1. These volume changes can be interpreted in terms of displacement of solvent from the cavity of α- cyclodextrin and/or changes in solvation of the 'guest' molecule.

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Chemistry, Organic

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