A systematic review of resting-state functional-MRI studies in major depression

L Wang; Daniel F Hermens; I B Hickie; Jim Lagopoulos

doi:10.1016/j.jad.2012.04.013

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A systematic review of resting-state functional-MRI studies in major depression

Journal article

Peer reviewed

A systematic review of resting-state functional-MRI studies in major depression

L Wang, Daniel F Hermens, I B Hickie and Jim Lagopoulos

Journal of Affective Disorders, Vol.142(1-3), pp.6-12

2012

DOI: https://doi.org/10.1016/j.jad.2012.04.013

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Abstract

resting state

fMRI

depression

bipolar

affective disorders

connectivity

Background: To evaluate the literature pertaining to the use of resting-state functional magnetic resonance imaging (fMRI) in Major Depression (MD). Methods: A search for papers published in English was conducted using MedLine, Embase, PsycINFO, OvidSP, and ScienceDirect with the following words: resting state, depression, MRI, affective, and default-mode. Results: The findings from 16 resting-state fMRI studies on MD are tabulated. Some common findings are discussed in further detail. Conclusion: The use of resting-state fMRI in MD research has yielded a number of significant findings that provide the basis for understanding the pathophysiology of depressive symptoms. Of particular note and deserving of further research are the roles of the cortico-limbic mood regulating circuit (MRC) and the interaction between task-positive and task-negative networks in MD. There is increasing interest in the use of resting-state fMRI in the study of psychiatric conditions, and continued improvement in technique and methodology will prove valuable in future research. © 2012 Elsevier B.V.

Details

Title: A systematic review of resting-state functional-MRI studies in major depression
Authors: L Wang (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
Publication details: Journal of Affective Disorders, Vol.142(1-3), pp.6-12
Publisher: Elsevier BV
Date published: 2012
DOI: 10.1016/j.jad.2012.04.013
ISSN: 0165-0327
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449175502621
Output Type: Journal article

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