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Published VersionCC BY V4.0, Open Access
Journal article
A systematic review of immunosuppressive risk factors and comorbidities associated with the development of crusted scabies
International Journal of Infectious Diseases, Vol.143, pp.1-9
2024
PMID: 38570134
Abstract
Objectives
Crusted scabies (CS, Norwegian scabies) is a severe form of scabies, characterized by hyper-infestation of Sarcoptes scabiei mites. CS is commonly associated with immunosuppression but is also reported in overtly immunocompetent individuals. We reviewed immunosuppressive risk factors and comorbidities associated with CS.
Methods
The National Library of Medicine (PubMed) database was reviewed for patient case reports of CS from January 1998 to July 2023. Two authors screened records for eligibility, extracted data, and one critically appraised the quality of the studies. Systematic review registration: PROSPERO CRD42023466126.
Results
A total of 436 records were identified, of which 204 were included for systematic review. From these, 683 CS patients were included. CS impacted both genders equally. Adults (21-59 years) were more commonly affected (45.5%) compared to children (0-20 years, 21%). Corticosteroid use was the most prevalent immunosuppressive risk factor identified (27.7% of all cases). About 10.2% of reports were associated with HIV/AIDS, and 8.5% with HTLV-1 infection. 10.5% of patients were overtly immunocompetent with no known risk factors. Overall, 41 (6.0%) died, many subsequent to secondary bacteremia.
Conclusion
This study represents the first systematic review undertaken on immunosuppressive risk factors associated with CS. This provides insights into trends of immunosuppression and mechanisms of CS development.
Details
- Title
- A systematic review of immunosuppressive risk factors and comorbidities associated with the development of crusted scabies
- Authors
- Gianni Bergamin - University of the Sunshine Coast, Queensland, School of HealthJoshua Hudson - University of the Sunshine Coast, Queensland, School of HealthBart J Currie - Charles Darwin UniversityKate Mounsey (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
- Publication details
- International Journal of Infectious Diseases, Vol.143, pp.1-9
- Publisher
- Elsevier Ltd
- Date published
- 2024
- DOI
- 10.1016/j.ijid.2024.107036
- ISSN
- 1878-3511; 1201-9712
- PMID
- 38570134
- Copyright note
- © 2024 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
- Data Availability
- The data supporting this article are available in the supplementary material.
- Organisation Unit
- School of Health - Biomedicine; School of Health; Marketing and Communications
- Language
- English
- Record Identifier
- 991023898902621
- Output Type
- Journal article
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