A systematic review and meta-analysis of proton magnetic resonance spectroscopy and mismatch negativity in bipolar disorder

K M Chitty; Jim Lagopoulos; R S C Lee; I B Hickie; Daniel F Hermens

doi:10.1016/j.euroneuro.2013.07.007

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A systematic review and meta-analysis of proton magnetic resonance spectroscopy and mismatch negativity in bipolar disorder

Journal article

Peer reviewed

A systematic review and meta-analysis of proton magnetic resonance spectroscopy and mismatch negativity in bipolar disorder

K M Chitty, Jim Lagopoulos, R S C Lee, I B Hickie and Daniel F Hermens

European Neuropsychopharmacology, Vol.23(11), pp.1348-1363

2013

DOI: https://doi.org/10.1016/j.euroneuro.2013.07.007

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Abstract

bipolar disorder

glutamate

anterior cingulate cortex

mismatch negativity

magnetic resonance spectroscopy

meta-analysis

frontal lobe

Aberrant glutamate neurotransmission has been implicated in the pathophysiology of bipolar disorder with accumulating evidence from imaging, post-mortem and pathology studies. Studies investigating in vivo changes to the glutamatergic system have not been as consistent and warrant clarification. Studies utilizing proton-magnetic resonance spectroscopy (1H-MRS) have reported increased levels of combined glutamate and glutamine ("Glx"), which have been linked to impairments in N-methyl-d-aspartate (NMDA) receptor function. Similarly, neurophysiological studies utilising mismatch negativity (MMN) as an index of NMDA receptor function, have reported impairments in bipolar disorder. Here, we provide a systematic review of the literature in regards to the concentration of Glx and the magnitude of MMN in bipolar disorder. Separate meta-analyses revealed that bipolar disorder was associated with increased Glx concentration and decreased MMN-both measured frontally. The current findings corroborate previous evidence indicating that bipolar disorder is characterized by a perturbed frontal glutamate system. These observed changes in bipolar disorder might manifest as impairments in neuronal-glial interactions that lead to disrupted neuronal output and ultimately result in the characteristic neurocognitive sequelae associated with this disorder. © 2013.

Details

Title: A systematic review and meta-analysis of proton magnetic resonance spectroscopy and mismatch negativity in bipolar disorder
Authors: K M Chitty (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
R S C Lee (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
Publication details: European Neuropsychopharmacology, Vol.23(11), pp.1348-1363
Publisher: Elsevier BV
Date published: 2013
DOI: 10.1016/j.euroneuro.2013.07.007
ISSN: 0924-977X
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449949902621
Output Type: Journal article

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