A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

Martina Sanderson-Smith; David M P De Oliveira; Julien Giglielmini; David J McMillan; Therese Vu; Jessica K Holien; Anna Henningham; Andrew C Steer; Debra E Bessen; James B Dale; Nigel Curtis; Bernard W Beall; Mark J Walker; Michael W Parker; Jonathan R Carapetis; Laurence Van Melderen; Kadaba S Sriprakash; Pierre R Smeesters

doi:10.1093/infdis/jiu260

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A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

Journal article

Open access

Peer reviewed

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

Martina Sanderson-Smith, David M P De Oliveira, Julien Giglielmini, David J McMillan, Therese Vu, Jessica K Holien, Anna Henningham, Andrew C Steer, Debra E Bessen, James B Dale, …

Journal of Infectious Diseases, Vol.210(8), pp.1325-1338

2014

DOI: https://doi.org/10.1093/infdis/jiu260

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Abstract

streptococcus pyogenes

molecular typing

vaccine development

Streptococcus pyogenes ranks amongst the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against Streptococcus pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for Streptococcus pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance and vaccine development.

Details

Title: A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development
Authors: Martina Sanderson-Smith (Author) - University of Wollongong
David M P De Oliveira (Author) - University of Wollongong
Julien Giglielmini (Author) - Institut Pasteur, France
David J McMillan (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Therese Vu (Author) - Queensland Institute of Medical Research
Jessica K Holien (Author) - St. Vincent's Institute of Medical Research
Anna Henningham (Author) - University of Queensland
Andrew C Steer (Author) - University of Melbourne
Debra E Bessen (Author) - New York Medical College, United States
James B Dale (Author) - University of Tennessee, United States
Nigel Curtis (Author) - University of Melbourne
Bernard W Beall (Author) - Centers for Disease Control and Prevention, United States
Mark J Walker (Author) - University of Queensland
Michael W Parker (Author) - University of Melbourne
Jonathan R Carapetis (Author) - University of Western Australia
Laurence Van Melderen (Author) - Universite Libre de Bruxelles, Belgium
Kadaba S Sriprakash (Author) - Queensland Institute of Medical Research
Pierre R Smeesters (Author) - Murdoch Children Research Institute
Publication details: Journal of Infectious Diseases, Vol.210(8), pp.1325-1338
Publisher: Oxford University Press
Date published: 2014
DOI: 10.1093/infdis/jiu260
ISSN: 0022-1899
Copyright note: Copyright © 2014 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Infectious Diseases following peer review. The definitive publisher-authenticated version is available online at: http://dx.doi.org/10.1093/infdis/jiu260
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450058002621
Output Type: Journal article

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